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FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
Sialyl-Lewis x (sLe x , CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for...
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The physiological and pathological roles and applications of sialyl Lewis x, a common carbohydrate ligand of the three selectins
In the past decades, the roles of carbohydrates in living organisms and their potential use in many fields have been extensively investigated. Sialyl...
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The sialyl-Tn antigen synthase genes regulates migration–proliferation dichotomy in prostate cancer cells under hypoxia
A low-oxygen (hypoxia) tumor microenvironment can facilitate chemotherapy and radiation therapy resistance in tumors and is associated with a poor...
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ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility
Expression of sialyl Lewis X (SLeX) is a well-documented event during malignant transformation of cancer cells, and largely associates with their...
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Mendelian randomization of circulating proteome identifies actionable targets in heart failure
BackgroundHeart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown.
Results ...
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Glycan structures and their recognition roles in the human blood group ABH/Ii, Lea, b, x, y and Sialyl Lea,x active cyst glycoproteins
Human ovarian cyst glycoproteins (HOC, cyst gps) isolated from pseudomucinous type of human ovarian cyst fluids is one of the richest and pioneer...
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The story of the Sda antigen and of its cognate enzyme B4GALNT2: What is new?
The structure Siaα2,3(GalNAcβ1,4)Gal- is the epitope of the Sd a antigen, which is expressed on the erythrocytes and secretions of the vast majority...
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CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis
Snail is a denoted transcriptional repressor that plays key roles in epithelial-mesenchymal transition (EMT) and metastasis. Lately, a plethora of...
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Fucosidases from the human gut symbiont Ruminococcus gnavus
The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation of gut bacteria species to...
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Chemical Synthesis of Gangliosides
Synthetic methodologies for gangliosides have evolved over the past three decades. The strategies for constructing ganglioside skeletons can...
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Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival...
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Other Non-α1,3Gal Antigens
Since understanding of the impact in xenoantigenic determinant Galα1,3Gal-R and anti-α1,3Gal Abs during xenoantigenic damages and injuries, other...
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Sialoglycovirology of Lectins: Sialyl Glycan Binding of Enveloped and Non-enveloped Viruses
On the cell sur “face”, sialoglycoconjugates act as receptionists that have an important role in the first step of various cellular processes that...
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Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype
Alterations in protein glycosylation in colorectal cancer (CRC) have been extensively studied using cell lines as models. However, little is known...
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Glycosylation editing: an innovative therapeutic opportunity in precision oncology
Cancer is still one of the most arduous challenges in the human society, even though humans have found many ways to try to conquer it. With our...
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Non-α1,3Gal Carbohydrate Antigenic Epitopes
Non-Gal (Non-α1,3-Gal) antigenic epitope is also targeted by the cellular immune system. Preformed natural non-Gal Abs do not cause HR in...
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First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Purpose of ReviewDescribe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning of MSCs in...
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Sialic Acid-Binding Ig-Like Lectins (Siglecs)
During the mid-1980s, in vitro rosette formation between macrophages and sheep erythrocytes was reported; however, sialidase treatment on...
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Glycans in Glycoimmunology
Carbohydrates (or glycans) are ubiquitous and display a broad range of biological functions and disease expressions. Without glycan-mediated events,...
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The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases
Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential roles in their social life. In Deuterostoma, sialic acids...
