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Identification of Functionally Significant Polymorphic Variants in miRNA Genes in Carotid Atherosclerosis
miRNAs are vital molecules of gene expression. They are involved in the pathogenesis of various common diseases, including atherosclerosis, its risk...
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Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review
Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 ...
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MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway
MicroRNA functions as an important part of the activity and development of immune cells. miR-499 has been demonstrated to play a significant role in...
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miRNA Regulome in Different Atherosclerosis Phenotypes
AbstractDysregulation of microRNA (miRNA) expression is associated with a susceptibility to many diseases, including atherosclerotic lesions of the...
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The relationship between B-cell lymphoma 2, interleukin-1β, interleukin-17, and interleukin-33 and the development of diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is among the main complications of diabetes mellitus and has been a major factor of renal failure. This study was...
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Age-Dependent Approach to Search for Genetic Variants Associated with Myocardial Infarction
AbstractMyocardial infarction (MI), one of the most common manifestations of cardiovascular system aging, is often fatal. The vast majority of...
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Pre-micro RNA-499 Gene Polymorphism rs3746444 T/C is Associated with Susceptibility to Rheumatoid Arthritis in Egyptian Population
Pre-miRNA-499 gene is associated with autoimmune disease. Mir-449 rs3746444 polymorphism is inconsistent for rheumatoid arthritis (RA). This study...
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Possible use of miRNAs-146a and -499 expression and their polymorphisms as diagnostic markers for rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disorder affecting the peripheral joints. Different microRNAs had been investigated in RA...
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The Myocardial Infarction Associated Variant in the MIR196A2 Gene and Presumable Signaling Pathways to Involve miR-196a2 in the Pathological Phenotype
Abstract—The heritable component of susceptibility to myocardial infraction (MI) remains unexplained, possibly due to the minor effects of genes,...
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Association of miRNA 30c, miRNA 181a and miRNA 570 SNPs with Bladder Cancer Risk in North Indian Population: A Pilot Study
miRNA play role in post transcriptional regulation of genes and serves a range of biological functions such as initiation, development, metastasis...
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Variability of the MIR196A2 Gene as a Risk Factor in Primary-Progressive Multiple Sclerosis Development
AbstractMultiple sclerosis is a chronic disease of the central nervous system, combining in its pathogenesis both autoimmune and neurodegenerative...
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Current insight into the roles of microRNA in vitiligo
Vitiligo is a common chronic depigmented skin disease characterized by melanocyte loss or dysfunction in the lesion. The pathogenesis of vitiligo has...
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Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis
Atherosclerosis (AT) is a chronic immuno-inflammatory disease characterized by inflammatory mediators and immune activation in arterial wall....
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Association of a potential functional mir-520f rs75598818 G > A polymorphism with breast cancer
Some of the single-nucleotide polymorphisms in miRNA genes have been studied to date to find their association with the risk of breast cancer (BC)....
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rs3746444 Polymorphism and Susceptibility to Hepatocellular Carcinoma: Evidence from Published Studies
The present study was undertaken to quantitatively evaluate the association between rs3746444 polymorphism and HCC risk. In this analysis with 667...
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Pharmacogenomics: Clinical Perspective, Strategies, and Challenges
Pharmacogenomics (PGx) defines the genetic basis of variability among individuals in response to drugs. It is an emerging discipline of medical...
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Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis
MicroRNAs (miRNAs) are a class of new non-coding RNA, which may play a more important role in the pathogenesis of human cancers. Rs2910164 in...
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miR-499 rs3746444 polymorphism is associated with cancer development among Asians and related to breast cancer susceptibility
To derive a more precise estimation of the relationship between miR - 499 rs3746444 polymorphism (A>G) and cancer risk, a meta-analysis was performed....
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Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer
The associations of SNPs rs11614913, rs2292832, and rs2910164 in miRNAs have been exploded in several independent studies and meta-analyses, but the...
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The association between common genetic variant of microRNA-499 and cancer susceptibility: a meta-analysis
Published data on the association between microRNA-499 (miR-499) rs3746444 T>C polymorphism and cancer susceptibility are inconclusive. To derive a...
