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Construction of a Pichia pastoris strain efficiently producing recombinant human granulocyte-colony stimulating factor (rhG-CSF) and study of its biological activity on bone marrow cells
Non-glycosylated, recombinant human granulocyte colony-stimulating factor (rhG-CSF), produced by Escherichia coli (filgrastim, leukostim) is widely...
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Combinatorial ethanol treatment increases the overall productivity of recombinant hG-CSF in E. coli: a comparative study
AbstractHuman granulocyte colony-stimulating factor (hG-CSF) is a cytokine that regulates the proliferation, maturation, and differentiation of...
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Correction to: Construction of a Pichia pastoris strain efficiently producing recombinant human granulocyte-colony stimulating factor (rhG-CSF) and study of its biological activity on bone marrow cells
The original publication has been updated. The acknowledgment was omitted from the original article and is published below.
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Dissecting thrombus-directed chemotaxis and random movement in neutrophil near-thrombus motion in flow chambers
BackgroundThromboinflammation is caused by mutual activation of platelets and neutrophils. The site of thromboinflammation is determined by...
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Immune dysregulation in sepsis: experiences, lessons and perspectives
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious...
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Development of recombinant human granulocyte colony-stimulating factor (nartograstim) production process in Escherichia coli compatible with industrial scale and with no antibiotics in the culture medium
AbstractThe granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that has important clinical applications for treating...
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Aqueous Two-Phase Systems for Cleanup and Recovery of Enzymes from Plants and Plant-Derived Extracts
The increasing interest of the biopharmaceutical industry to exploit plants as a commercially viable production system is demanding the development...
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Current trends in biopharmaceuticals production in Escherichia coli
Since the manufacture of the first biotech product for a fledgling biopharmaceutical industry in 1982, Escherichia coli , has played an important role...
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Return to work after cell transplantation in patients with angiitis-induced critical limb ischaemia and factors related: a single-centre retrospective cohort study
BackgroundAngiitis-induced critical limb ischaemia (AICLI) patients, who are usually young and have a high amputation rate, always lose their ability...
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The peripheral blood mononuclear cells versus purified CD34+ cells transplantation in patients with angiitis-induced critical limb ischemia trial: 5-year outcomes and return to work analysis—a randomized single-blinded non-inferiority trial
BackgroundsPatients with AICLI constitute a considerable proportion of NO-CLI patients and cannot be treated with surgical or endovascular treatment....
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Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A
BackgroundHuman erythropoiesis is a tightly regulated, multistep process encompassing the differentiation of hematopoietic stem cells (HSCs) toward...
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MicroRNA in lung cancer—a novel potential way for early diagnosis and therapy
Lung cancer is the most common cause of cancer-related deaths in the world. One of the reasons of poor prognosis and high mortality of lung cancer...
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Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation: a multicenter study
The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation (HBMT) on hematological malignances are well established. Previous...
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The Statue of Cytokines Therapy in Blood Transfusion Running Cytokine and Blood Transfusion
AbstractIn order to improve the patient’s condition, the transfusion of blood products is used, however, there are problems with blood transfusion...
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The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice
Backgroundβ-Thalassaemia is a clinically common cause of hereditary haemolytic anaemia stemming from mutations in important functional regions of the...
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Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry
The immune monocyte/phagocyte system (MPS) includes numerous cell subsets of the myeloid lineage including monocyte, macrophage, and dendritic cell...
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Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway
Sarcodon imbricatus , a rare medicinal and edible fungus, has various pharmacological bioactivities. We investigated the effects of S. imbricatus ...
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Large Biomolecules: An Overview
The main strategy for studying life sciences is to understand the major challenges encountered by humans for survival and to resolve various issues...
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Purification Method for Recombinant hG-CSF by Affinity Chromatography
The human granulocytic colony-stimulating factor (hG-CSF) acts mainly by promoting the maturation of granulocytes and stimulating their phagocytic...
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α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome
The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has...