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Reverse engineering morphogenesis through Bayesian optimization of physics-based models
Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is...
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Reverse engineering environmental metatranscriptomes clarifies best practices for eukaryotic assembly
BackgroundDiverse communities of microbial eukaryotes in the global ocean provide a variety of essential ecosystem services, from primary production...
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Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature
AbstractSaccharomyces cerevisiae scarcely grows on minimal media with acetic acid, acidic pH, and high temperatures. In this study, the adaptive...
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Reverse-engineering the cortical architecture for controlled semantic cognition
We employ a reverse-engineering approach to illuminate the neurocomputational building blocks that combine to support controlled semantic cognition:...
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Soil microbiome engineering for sustainability in a changing environment
Recent advances in microbial ecology and synthetic biology have the potential to mitigate damage caused by anthropogenic activities that are...
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Sea-level rise can reverse the conditions that promote the spread of ecosystem engineers
Climate change and its consequences such as sea-level rise will modify environmental gradients, altering the spatial spread and persistence of plant...
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Engineering SARS-CoV-2 using a reverse genetic system
Reverse genetic systems are a critical tool for studying viruses and identifying countermeasures. In response to the ongoing COVID-19 pandemic, we...
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Engineering Bacillus subtilis J46 for efficient utilization of galactose through adaptive laboratory evolution
Efficient utilization of galactose by microorganisms can lead to the production of valuable bio-products and improved metabolic processes. While Bacill...
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Bacteriophage genome engineering with CRISPR–Cas13a
Jumbo phages such as Pseudomonas aeruginosa ФKZ have potential as antimicrobials and as a model for uncovering basic phage biology. Both pursuits are...
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Bacterial genome engineering using CRISPR-associated transposases
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated transposases have the potential to transform the technology landscape...
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Advanced Bioink Materials for Tissue Engineering Applications
Purpose of ReviewGlobal demand for organ transplantation or tissue regeneration is constantly increasing. Advances in tissue engineering and...
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Engineering circular RNA for molecular and metabolic reprogramming
The role of messenger RNA (mRNA) in biological systems is extremely versatile. However, it’s extremely short half-life poses a fundamental...
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The Regenerative Microenvironment of the Tissue Engineering for Urethral Strictures
Urethral stricture caused by various reasons has threatened the quality of life of patients for decades. Traditional reconstruction methods,...
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Metabolic networks: biology meets engineering sciences
A hallmark of systems biology is the interdisciplinary approach to the complexity of biological systems, in which mathematical modeling constitutes...
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Use of Cas9 Targeting and Red Recombination for Designer Phage Engineering
Bacteriophages (phages) are natural antibiotics and biological nanoparticles, whose application is significantly boosted by recent advances of...
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Genetic Engineering in Mycobacteria
AbstractGenetic tools for targeted modification of the mycobacterial genome contribute to the understanding of the physiology and virulence...
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Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering....
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An expanded CRISPR–Cas9-assisted recombineering toolkit for engineering genetically intractable Pseudomonas aeruginosa isolates
Much of our current understanding of microbiology is based on the application of genetic engineering procedures. Since their inception (more than 30...
