Search
Search Results
-
Rat Embryonic Stem Cell Transgenesis
The availability of reliable germline competent rat embryonic stem cell (ESC) lines that can be genetically manipulated provides an important tool...
-
Developmental Toxicity Using the Rat Whole Embryo Culture
In vivo and in vitro experiments have been used to investigate the effect of drugs, chemical agents, growth factors, vitamins, etc., on embryonic...
-
Gene Targeting in Rat Embryonic Stem Cells
Rat germline-competent embryonic stem (ES) cell lines have been available since 2008, and rat models with targeted mutations have been successfully...
-
Genome Editing of Rat
Many genetically engineered rat strains have been produced by the development of genome editing technology, although it used to be technical...
-
Electroporation-Mediated CRISPR/Cas9 Genome Editing in Rat Zygotes
Genetic engineering in the rat has been revolutionized by the development of CRISPR-based genome editing tools. Conventional methods for inserting...
-
Precision-Cut Slice Culture Method for Rat Placenta
Organotypic slice cultures provide several advantages over primary and cell line culture models. Unlike monolayer cultures, organotypic slice...
-
Genome Editing in Mouse and Rat by Electroporation
Many genome-edited mouse and rat strains have been produced using engineered endonucleases, including zinc finger nuclease (ZFN), transcription...
-
Higher rat abundance in greener urban areas
Urban greening has become an increasingly popular strategy to improve urban life and human health. However, there are indications that the presence...
-
Induction of Primordial Germ Cell-Like Cells from Rat Pluripotent Stem Cells
In vitro induction of primordial germ cell like-cells (PGCLCs) from pluripotent stem cells (PSCs) is a robust method that will contribute to...
-
Products of Selenite/Thiols Interaction Have Reducing Properties, Cleave Plasmid DNA and Decrease Rat Blood Pressure and Tension of Rat Mesenteric Artery
Selenium compounds exert their antioxidant activity mostly when the selenium atom is incorporated into selenoproteins. In our work, we tested the...
-
Age-Adjustment Expertise in Rat Models of Human Diseases
Rat models are the most frequently used models in preclinical and clinical trials because of having smaller body size, easier maintenance, presenting...
-
CRISMERE Chromosome Engineering in Mouse and Rat
CRISPR/Cas9 technology is a versatile tool for engineering biology that has dramatically transformed our ability to manipulate genomes. In this...
-
Insulin and circadian rhythm genes of the Nile rat (Arvicanthis niloticus) are conserved and orthologous to those in the rat, mouse and human
The African grass or Nile rat (NR) ( Arvicanthis niloticus ) is a herbivorous diurnal rodent which is used as a biological model for research on type 2...
-
Genetic and Immunohistochemistry Tools to Visualize Rat Macrophages In Situ
Macrophages contribute to many aspects of development and homeostasis, innate and acquired immunity, immunopathology, and tissue repair. Every tissue...
-
Reversal of biological age in multiple rat organs by young porcine plasma fraction
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young...
-
Rat microbial biogeography and age-dependent lactic acid bacteria in healthy lungs
The laboratory rat emerges as a useful tool for studying the interaction between the host and its microbiome. To advance principles relevant to the...
-
Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma
IntroductionUntargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus,...
-
Basic urban services fail to neutralise environmental determinants of ‘rattiness’, a composite metric of rat abundance
Globally, low-income urban communities suffer from poor provision of services and degraded environments, favouring opportunistic zoonotic reservoirs,...
-
Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration
Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until...
-
A common gene signature of the right ventricle in failing rat and human hearts
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic...
