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Proton transfer and conformational changes along the hydrogen bond network in heliorhodopsin
Heliorhodopsin releases a proton from the Schiff base during the L-state to M-state transition but not toward the protein bulk surface. Here we...
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Directed proton transfer from Fo to F1 extends the multifaceted proton functions in ATP synthase
The role of protons in ATP synthase is typically considered to be energy storage in the form of an electrochemical potential, as well as an operating...
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Tools for analyzing protonation states and for tracing proton transfer pathways with examples from the Rb. sphaeroides photosynthetic reaction centers
Protons participate in many reactions. In proteins, protons need paths to move in and out of buried active sites. The vectorial movement of protons...
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Mechanisms of inward transmembrane proton translocation
Proton transport is indispensable for cell life. It is believed that molecular mechanisms of proton movement through different types of...
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Comparison of proton transfer paths to the QA and QB sites of the Rb. sphaeroides photosynthetic reaction centers
The photosynthetic bacterial reaction centers from purple non-sulfur bacteria use light energy to drive the transfer of electrons from cytochrome c ...
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Identification of amino acid residues in a proton release pathway near the bacteriochlorophyll dimer in reaction centers from Rhodobacter sphaeroides
Insight into control of proton transfer, a crucial attribute of cellular functions, can be gained from investigations of bacterial reaction centers....
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Structural, Functional and Molecular Dynamics Examination of a de novo cloned Otopetrin-like Proton Channel in crayfish
Proton channels play a crucial role in many biological functions, as they are responsible for the selective transport of protons across cell...
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Energetics and dynamics of the proton shuttle of carbonic anhydrase II
Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton...
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Features of the Mechanism of Proton Transport in ESR, Retinal Protein from Exiguobacterium sibiricum
AbstractRetinal-containing light-sensitive proteins – rhodopsins – are found in many microorganisms. Interest in them is largely explained by their...
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Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes
ObjectivesThe applicability of proton-transfer-reaction mass spectrometry (PTR-MS) as a versatile online monitoring tool to increase consistency and...
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Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and...
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Proton-pum** photoreceptor controls expression of ABC transporter by regulating transcription factor through light
Light is a significant factor for living organisms with photosystems, like microbial rhodopsin—a retinal protein that functions as an ion pump,...
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Deep learning driven de novo drug design based on gastric proton pump structures
Existing drugs often suffer in their effectiveness due to detrimental side effects, low binding affinity or pharmacokinetic problems. This may be...
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β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis
Gamma-aminobutyric acid type A receptors (GABA A Rs) are ligand gated channels mediating inhibition in the central nervous system. Here, we identify a...
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Evolutionary diversity of proton and water channels on the oxidizing side of photosystem II and their relevance to function
One of the reasons for the high efficiency and selectivity of biological catalysts arise from their ability to control the pathways of substrates and...
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Introduction of a Sodium-Binding Motif into Subunits a and c of Bacillus sp. PS3 Proton F-ATPase Does Not Result in Sodium Specificity of the Enzyme
AbstractIn bacteria, F-type ATPase (F-ATPase) plays a key role in bioenergetics and couples ATP synthesis/hydrolysis with the transport of ions (H + ...
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Electron Transport in Chloroplasts: Regulation and Alternative Pathways of Electron Transfer
AbstractThis work represents an overview of electron transport regulation in chloroplasts as considered in the context of structure-function...
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Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel
Voltage-clamp fluorometry (VCF) supplies information about the conformational changes of voltage-gated proteins. Changes in the fluorescence...
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Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
Ionising radiation (IR) is widely used in cancer treatment, including for head and neck squamous cell carcinoma (HNSCC), where it induces significant...
