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Intracellular Lipids during In Vivo and In Vitro Preimplantation Embryo Development in Mice
AbstractInvestigating the role of lipids in mammalian preimplantation development is an important task in modern embryology. The aim of this study...
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The transcription factor ELF5 is essential for early preimplantation development
BackgroundDuring early embryonic development, the cell adhesion molecule E-cadherin encoded by the Cdh1 gene plays a vital role in providing proper...
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Preimplantation Genetic Testing
The two most crucial factors limiting the success of assisted reproduction are the quality of the embryo and the endometrium. The lacuna in the...
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Analysis of the Development of insrr Knockout Mouse Preimplantation Embryos
AbstractMaintaining an optimal acid-base balance of the organism has a pivotal role in the regulation of metabolism. It is provided by the...
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mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo
BackgroundMetabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase...
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Evaluating histone modification analysis of individual preimplantation embryos
BackgroundWe previously reported a modification of the CUT&Tag method (NTU-CAT) that allows genome-wide histone modification analysis in individual...
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Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development
Preimplantation embryo development is characterized by drastic nuclear reprogramming and dynamic stage-specific gene expression. Key regulators of...
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An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells
Pigs share anatomical and physiological traits with humans and can serve as a large-animal model for translational medicine. Bona fide porcine...
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Single-Cell mRNA-sncRNA Co-sequencing of Preimplantation Embryos
The development of single-cell multiomics has provided the ability to systematically investigate cellular diversity and heterogeneity in different...
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ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
BackgroundReactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial...
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Influence of the storage conditions of embryo culture media on mouse development
The culture of preimplantation embryos in vitro is an important method for human and mouse reproductive technology. This study aims to investigate...
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Manual Dissociation of Mammalian Preimplantation Embryos for Single-Cell Genomics
Single-cell genomics allow the characterization and quantification of molecular heterogeneity from a wide variety of tissues. Here, we describe the...
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The RNA m6A landscape of mouse oocytes and preimplantation embryos
Despite the significance of N 6 -methyladenosine (m 6 A) in gene regulation, the requirement for large amounts of RNA has hindered m 6 A profiling in...
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BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos
BackgroundDuring mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified:...
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Guinea Pig Preimplantation Embryos: Generation, Collection, and Immunofluorescence
Studying various animal models is important for comparative biology and to better understand evolutionary development. Furthermore, when aiming to...
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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it...
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Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development
Lipids are indispensable for energy storage, membrane structure and cell signalling. However, dynamic changes in various categories of endogenous...
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Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development
Abstract —Serotonin is a regulator of early embryonic development and has a complete functional system in preimplantation mammalian embryos. In the...
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A long-read sequencing and SNP haplotype-based novel preimplantation genetic testing method for female ADPKD patient with de novo PKD1 mutation
The autosomal dominant form of polycystic kidney disease (ADPKD) is the most common hereditary disease that causes late-onset renal cyst development...
