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CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape
It is known that about 10 circular RNAs (circRNAs) can encode functional polypeptides in higher mammals. However, it is not clear whether the...
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Using the local symmetry in amino acids sequences of polypeptides to improve the predictive potential of models of their inhibitor activity
The minimal inhibitory concentrations (pMIC) are a valuable measure of the biological activity of polypeptides. Numerical data on the pMIC are...
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Cucumber seed polypeptides regulate RANKL-induced osteoclastogenesis through OPG/RANKL/RANK and NF-κB
Postmenopausal osteoporosis (PMOP) is a common disease that endangers the health of elderly women. Cucumber seeds have shown excellent therapeutic...
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Polypeptide-Based Multicomponent Materials: From Design to Applications
Polypeptides are of great interest to material scientists because of their functional versatility. The functionality of single-component polypeptide...
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Organic anion-transporting polypeptides are involved in the elimination of insecticides from the red flour beetle, Tribolium castaneum
AbstractOrganic anion-transporting polypeptides (OATPs) are integral membrane transporters that mediate cellular uptake of a broad range of...
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Influence of Ionic Strength on Adsorption of Polypeptides on Lipid Membranes: Theoretical Analysis
AbstractTheoretical analysis of the effect of the ionic strength of a solution on the surface (zeta) potential of liposomes formed by an anionic...
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Amino Acid Composition, Antioxidant, α-Glucosidase and α-Amylase Inhibitory Activities of the Enzymic Polypeptide from Acer truncatum Seed Meal
As a new food raw material, Acer truncatum seed has been used in the production of edible oil. However, the research on the processing residue (seed...
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A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells
The advance of high-throughput sequencing enhances the discovery of short ORFs embedded in long non-coding RNAs (lncRNAs). Here, we uncovered the...
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Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force
Nanopores have recently been used to identify and fingerprint proteins. However, because proteins, unlike DNA, do not have a uniform charge, the...
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High-resolution structure and biochemical properties of the LH1–RC photocomplex from the model purple sulfur bacterium, Allochromatium vinosum
The mesophilic purple sulfur phototrophic bacterium Allochromatium ( Alc .) vinosum (bacterial family Chromatiaceae ) has been a favored model for...
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Nuclear Magnetic Resonance-Guided Structural Analysis of Moderate-Affinity Protein Complexes with Intrinsically Disordered Polypeptides
Binding affinity of an individual binding site of an intrinsically disordered protein for its folded partner may be moderate. In such cases, a...
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Evaluation of haemolymph phenoloxidase activity from the grub of Zophobas morio as a predictor of immune response
In insects, enzyme phenoloxidase plays a critical role in cuticular sclerotisation and defensive functions. In the present investigation, haemolymph...
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An LH1–RC photocomplex from an extremophilic phototroph provides insight into origins of two photosynthesis proteins
Rhodopila globiformis is the most acidophilic of anaerobic purple phototrophs, growing optimally in culture at pH 5. Here we present a cryo-EM...
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Quality control of proteins in the mitochondrion
The quality control of proteins within mitochondria is ensured by conserved and ubiquitous ATP-dependent molecular chaperones and proteases, present...
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Silver nanoparticles induced with aqueous black carpenter ant extract selectively inhibit the growth of Pseudomonas aeruginosa
Aqueous black carpenter ant extract (ABCAE) was used to synthesize silver nanoparticles (AgNPs). The ABCAE was rich in water-soluble compounds such...
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High-throughput identification of dominant negative polypeptides in yeast
Dominant negative polypeptides can inhibit protein function by binding to a wild-type subunit or by titrating a ligand. Here we use high-throughput...
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CAT tails drive degradation of stalled polypeptides on and off the ribosome
Stalled translation produces incomplete, ribosome-tethered polypeptides that the ribosome-associated quality control (RQC) pathway targets for...
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Gene Stacking and Stoichiometric Expression of ER-Targeted Constructs Using “2A” Self-Cleaving Peptides
Simultaneous stoichiometric expression of multiple genes plays a major part in modern research and biotechnology. Traditional methods for...
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Reactivity of amino acids and short peptide sequences: identifying bioactive compounds via DFT calculations
Bioactive peptides are short amino acid sequences that play important roles in various physiological processes, including antioxidant and protective...
