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TET activity safeguards pluripotency throughout embryonic dormancy
Dormancy is an essential biological process for the propagation of many life forms through generations and stressful conditions. Early embryos of...
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Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation
Thioredoxin interacting protein (Txnip) is a stress-responsive factor regulating Trx1 for redox balance and involved in diverse cellular processes...
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Transformation of Pluripotency States during Morphogenesis of Mouse and Human Epiblast
AbstractThe pluripotent status of a cell in vivo is spatio-temporally regulated within embryogenesis and is determined by the processes of...
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Suspension culture improves iPSC expansion and pluripotency phenotype
BackgroundInduced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets,...
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Tumor suppressor let-7 acts as a key regulator for pluripotency gene expression in Muse cells
In embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), the expression of an RNA-binding pluripotency-relevant protein, LIN28, and...
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Ubiquitin-Proteasome System in the Regulation of Cell Pluripotency and Differentiation
AbstractEmbryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) demonstrate unique abilities for continuous self-renewal and...
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Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat
Embryonic stem cells (ESCs) exhibit unique attributes of boundless self-renewal and pluripotency, making them invaluable for fundamental...
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The Impact of Stimulation and Suppression of NAD+ Biosynthesis on the Maintenance of Pluripotency of Mouse Embryonic Stem Cells
AbstractNicotinamide adenine dinucleotide (NAD + ) plays a key role in cell metabolism and signaling. In recent years, evidence has accumulated that...
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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
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Inhibition of TGF-β pathway improved the pluripotency of porcine pluripotent stem cells
Porcine pluripotent stem cells had been derived from different culture systems. PeNK6 is a porcine pluripotent stem cell line that we established...
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A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs
A comprehensive and precise definition of the pluripotency gene regulatory network (PGRN) is crucial for clarifying the regulatory mechanisms in...
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Learning Towards Maturation of Defined Feeder-free Pluripotency Culture Systems: Lessons from Conventional Feeder-based Systems
Pluripotent stem cells (PSCs) are widely recognized as one of the most promising types of stem cells for applications in regenerative medicine,...
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Characterization of a Distinct State in the Continuum of Pluripotency Facilitated by Inhibition of PKCζ in Mouse Embryonic Stem Cells
Inhibition of PKC (PKCi) signaling maintains pluripotency of embryonic stem cells (ESCs) across different mammalian species. However, the position of...
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Cell-type dependent regulation of pluripotency and chromatin remodeling genes by hydralazine
BackgroundThe generation of induced pluripotent stem cells has opened the field of study for stem cell research, disease modeling and drug...
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FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells
BackgroundThe FACT complex is a conserved histone chaperone with critical roles in transcription and histone deposition. FACT is essential in...
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Spontaneous spheroids from alveolar bone-derived mesenchymal stromal cells maintain pluripotency of stem cells by regulating hypoxia-inducible factors
BackgroundSpontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells....
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LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4
BackgroundPancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be...
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Dissecting the Role of the Ccr4–Not Deadenylase Complex in Pluripotency and Differentiation
In this chapter, we describe methods and assays to examine the role of the Ccr4–Not mRNA deadenylase complex in regulating mouse embryonic stem cell...
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Ubiquitin–Proteasome System in the Induction and Maintenance of Cellular Pluripotency
AbstractPluripotent embryonic stem cells (ESCs) are derived from preimplantation blastocysts and can differentiate into all types of somatic cells....
