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Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions
Ischemic stroke induces neovascularization of the injured tissue as an attempt to promote structural repair and neurological recovery. Angiogenesis...
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Pericyte Biology in the Optic Nerve and Retina
Purpose of ReviewPericytes are perivascular cells abundantly present in capillaries of multiple tissues and organs, especially in the central nervous...
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Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp
BackgroundHuman dental pulp stem cells represent a mesenchymal stem cell niche localized in the perivascular area of dental pulp and are...
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A Bioengineered Model for Studying Vascular-Pericyte Interactions of the Placenta
Investigating the complex cellular interactions of the placenta has remained, until now, a challenge in the field. Given the ethical limitations of...
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Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects
Antidiabetic sodium-glucose cotransporter 2 (SGLT2) inhibitors have attracted attention for their cardiorenal-protective properties beyond their...
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The therapeutic value of adipose-derived pericyte transplantation after intracerebral hemorrhage in rats
Intracerebral hemorrhage (ICH) is a devastating cerebrovascular associated with inflammation and BBB disruption. Pericytes plays a critical role in...
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Manipulating Pericyte Function with MicroRNAs
MicroRNAs (miRNAs) are expressed in all cell types, including pericytes, and play essential roles in vascular development, homeostasis, and disease....
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Analyses of the pericyte transcriptome in ischemic skeletal muscles
BackgroundPeripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the...
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The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis
BackgroundIt is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently...
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A Metabolomics-Based Approach to Identify Lineage Guiding Molecules in Pericyte Cultures
We report the use of self-assembled peptide (F2/S) hydrogels and cellular metabolomics to identify a number of innate molecules that are integral to...
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Visualizing Pericyte Mimicry of Angiotropic Melanoma by Direct Labeling of the Angioarchitecture
In addition to intravascular dissemination, angiotropic melanoma cells have the propensity to spread along the external surface of blood vessels in a...
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Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
BackgroundPericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and...
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Assessment of Pericyte Phenotype by Flow Cytometry
Pericytes are mural cells closely associated with endothelial cells in capillaries and microvessels. They are precursors of mesenchymal stem/stromal...
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Brain pericytes in culture display diverse morphological and functional phenotypes
Pericytes play several important functions in the neurovascular unit including contractile control of capillaries, maintenance of the BBB, regulation...
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Characterization of Human Pericyte Phenotype by Immunohistochemistry
Pericytes are found in all vascularized organs and are defined anatomically as perivascular cells that closely surround endothelial cells in...
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The Role of Pericytes in Tumor Angiogenesis
Pericytes are branched cells surrounded by the basement membrane (BM) of capillaries and post-capillary venules. Pericytes are involved in the...
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C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension
Pericyte dysfunction, with excessive migration, hyperproliferation, and differentiation into smooth muscle-like cells contributes to vascular...
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Orai, RyR, and IP3R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes
Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties,...
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Skeletal Muscle-Resident Pericyte Responses to Conditions of Use and Disuse
Skeletal muscle structure and function are dependent on the presence or absence of mechanical cues in the tissue microenvironment. High intensity or...
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Challenges and Perspectives on the Use of Pericytes in Tissue Engineering
Purpose of ReviewThe field of tissue engineering is driven by the need to provide functional equivalents of native tissues that can be used for...
