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Going beyond established model systems of Alzheimer’s disease: companion animals provide novel insights into the neurobiology of aging
Alzheimer’s disease (AD) is characterized by brain plaques, tangles, and cognitive impairment. AD is one of the most common age-related dementias in...
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Novel reaction systems for catalytic synthesis of structured phospholipids
AbstractPhospholipids are distinctive, adaptable molecules that are crucial to numerous biological systems. Additionally, their various architectures...
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A novel hybrid model to predict concomitant diseases for Hashimoto’s thyroiditis
Hashimoto’s thyroiditis is an autoimmune disorder characterized by the destruction of thyroid cells through immune-mediated mechanisms involving...
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A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions
A quantitative systems pharmacology (QSP) model of the pathogenesis and treatment of SARS-CoV-2 infection can streamline and accelerate the...
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Investigation of a novel biofilm model close to the original oral microbiome
AbstractA more optimized culture medium used in vitro to mimic the bacterial composition of original oral flora as similar as possible remains...
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Generation of a novel three-dimensional scaffold-based model of the bovine endometrium
Bovine in vitro endometrial models that resemble tissue function in vivo are needed to study infertility, long-term uterine alterations induced by...
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A novel model to evaluate spatial structure in thinned conifer-broadleaved mixed natural forests
In order to ensure the effective analysis and reconstruction of forests, it is key to ensure the quantitative description of their spatial structure....
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Model organisms and systems in neuroethology: one hundred years of history and a look into the future
The Journal of Comparative Physiology lived up to its name in the last 100 years by including more than 1500 different taxa in almost 10,000...
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Application of gabapentinoids and novel compounds for the treatment of benzodiazepine dependence: the glutamatergic model
BackgroundCurrent approaches for managing benzodiazepine (BZD) withdrawal symptoms are daunting for clinicians and patients, warranting novel...
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Efficient dilution-to-extinction isolation of novel virus–host model systems for fastidious heterotrophic bacteria
Microbes and their associated viruses are key drivers of biogeochemical processes in marine and soil biomes. While viruses of phototrophic...
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Characterization of aggregate-stabilized dissolved organic matter release - A novel approach to determine soil health advances of conservation farming systems
PurposeSince principles of conservation agriculture mimic the soil conditions of undisturbed natural soils, linking aggregation and dissolved organic...
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A Novel Combined Embedding Model Based on Heterogeneous Network for Inferring Microbe-Metabolite Interactions
The metabolome serves as a crucial intermediary between the microbiome and its host, playing a key role in revealing their biological functions....
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Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives
Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu 2 L 1 Cl 4 , Cu 2 L 2 Cl 4 ) and...
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A novel lipid metabolism-based risk model associated with immunosuppressive mechanisms in diffuse large B-cell lymphoma
BackgroundThe molecular diversity exhibited by diffuse large B-cell lymphoma (DLBCL) is a significant obstacle facing current precision therapies....
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A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant...
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FoldPAthreader: predicting protein folding pathway using a novel folding force field model derived from known protein universe
Protein folding has become a tractable problem with the significant advances in deep learning-driven protein structure prediction. Here we propose...
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Construction and validation of a novel Ferroptosis-related gene signature predictive model in rectal Cancer
BackgroundRectal cancer (RC) is one of the most common malignant tumors. Ferroptosis is an iron-dependent form of cell death, which plays an...
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Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish
Clinical sequencing efforts continue to identify novel putative oncogenes with limited strategies to perform functional validation in vivo and study...
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Extracellular vesicles, a novel model linking bacteria to ferroptosis in the future?
AbstractFerroptosis is a recently discovered modulated cell death mechanism caused by the accumulation of iron-dependent lipid peroxides to toxic...
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Generation of novel in vitro flexible kidney organoid model to investigate the role of extracellular vesicles in induction of nephrogenesis
BackgroundDuring kidney organogenesis, metanephric mesenchyme (MM) and ureteric bud (UB) interact reciprocally to form nephrons. Signaling stimuli...
