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Modern therapies of nonsmall cell lung cancer
Lung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender,...
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A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ...
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Knockdown of growth differentiation factor-15 inhibited nonsmall cell lung cancer through inactivating PTEN/PI3K/AKT signaling pathway
BackgroundNon-small cell lung cancer (NSCLC) is characterized by high morbidity and mortality in the world. Growth and differentiation factor 15...
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Double homeobox a pseudogene 8/miR-223-3p/PFN2 modulates radiosensitivity in lung cancer
BackgroundLong noncoding RNA double homeobox A pseudogene 8 (DUXAP8) was revealed to facilitate lung cancer progression in vitro, but the impacts of...
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PLEKHH2 binds β-arrestin1 through its FERM domain, activates FAK/PI3K/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer
PLEKHH2 is an important FERM domain containing-protein. However, the role of PLEKHH2 in human solid tumors has not been reported yet. We report that...
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Future Perspectives of Exosomal Payload of miRNAs in Lung Cancer
Exosomes are nanovesicles, which were first described in 1983 as a method by which cells disposed of their metabolic waste. Since the publication of...
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Future Perspectives of Exosomal Payload of miRNAs in Lung Cancer
Exosomes are nanovesicles, which were first described in 1983 as a method by which cells disposed of their metabolic waste. Since the publication of...
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Cannabis and Cancer
The International Agency for Research on Cancer report on the global burden of cancer estimated 18.1 million new cancer cases (17.0 million excluding...
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CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer
Lung cancer is one of the most common reasons for cancer-induced mortality across the globe, despite major advancements in the treatment strategies...
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Regulome-based characterization of drug activity across the human diseasome
Drugs are expected to recover the cell system away from the impaired state to normalcy through disease treatment. However, the understanding of gene...
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Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer
Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients. Herein, we...
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Protein–Protein Interactions in Cancer
Cancerous state is often associated with the aberrant expression of several critical proteins, which in turn, modulate interactions with other...
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Ferroptosis as a potential target for cancer therapy
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging...
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Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells
Various treatment options, such as molecular targeted drugs and immune checkpoint blockades, are available for patients with cancer. However, some...
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A glimpse into novel acylations and their emerging role in regulating cancer metastasis
Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large...
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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1...
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Sirtuin 6 Is a Critical Epigenetic Regulator of Cancer
Sirtuin 6 (SIRT6) is a member of the mammalian sirtuin family with deacetylase, deacylase, and mono-ADP-ribosyl-transferase activities. It is a...
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Treatment of Cancer Using Combination of Herbal and Novel Drug Delivery System
Nanotechnology and nanoengineering tend to generate significant scientific and technological push on in diverse domain including medicine and...
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Long noncoding RNA LINC00518 contributes to proliferation and metastasis in lung adenocarcinoma via the miR-335-3p/CTHRC1 Axis
Long intergenic nonprotein coding RNA 518 (LINC00518) is recognized to impart cancer proliferation and metastasis in lung adenocarcinoma (LUAD)....
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Regulation of IL33 Gene Expression by SP1 and Foxa1 in Breast and Lung Cancer Cells
AbstractInterleukin-33 (IL-33) is a member of the IL-1 cytokine family, primarily known as a mediator of the humoral immune response. It provides...
