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Neurotrophin growth factors and their receptors as promising blood biomarkers for Alzheimer’s Disease: a gene expression analysis study
BackgroundAlzheimer’s disease (AD) is a multifaceted neurological ailment affecting more than 50 million individuals globally, distinguished by a...
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Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat
The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR...
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Delivery of neurotrophin-3 by RVG-Lamp2b-modified mesenchymal stem cell-derived exosomes alleviates facial nerve injury
We aim to investigate the effect of RVG-Lamp2b-modified exosomes (exos) loaded with neurotrophin-3 (NT-3) on facial nerve injury. Exos were collected...
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Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity
AbstractNeurotrophin receptors regulate neuronal survival and network formation, as well as synaptic plasticity in the brain via interaction with...
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Relationship between Blood Microbiome and Neurotrophin Levels in Different Metabolic Types of Obesity
AbstractBlood bacterial DNA is one of the pathogen-associated molecular patterns whose signaling pathways can alter the expression of...
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Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels
BackgroundEpilepsy is one of the most common neurological disorders, and it places a significant economic strain on the healthcare system around the...
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Biochemical Assessments of Neurotrophin-3 and Zinc Involvement in the Pathophysiology of Pediatric Febrile Seizures
Febrile seizures (FSs) are a common occurrence in young children and a serious concern in pediatric practice; nevertheless, the causes and mechanisms...
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Risperidone Reduces Matrix Metalloproteinase-9 and Increases Neurotrophin-3 in Schizophrenia Spectrum of Disorder
Even though earlier studies have reported alteration in the markers of synaptic plasticity (Matrix metalloproteinase-9 [MMP-9] and Neurotrophin-3...
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The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties
AbstractThe dimeric dipeptide mimetic hexamethylenediamide bis -( N -monosuccinyl- L -asparaginyl- L -asparagine) (GTS-301) was created on the basis of the...
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Neurotrophic Biomarkers
Neurotrophins are proteins that exert profound effects on cell survival and activity within the central nervous system, playing crucial roles in the...
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Intranasal delivery of NGF rescues hearing impairment in aged SAMP8 mice
Hearing loss impacts the quality of life and affects communication resulting in social isolation and reduced well-being. Despite its impact on...
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Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is characterized by progressive cognitive decline and a reduction in hippocampal neurotrophins, in which...
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Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons
Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due...
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The Effect of Exercise on Mesenchymal Stem Cells and their Application in Obesity Treatment
Mesenchymal stem cells (MSCs) have demonstrated considerable potential in tissue repair and the treatment of immune-related diseases, but there are...
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Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells
Lipid-induced toxicity is part of several human diseases, but the mechanisms involved are not fully understood. Fatty liver is characterized by the...
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BDNF Prodomain Inhibits Neurotransmitter Quantal Release in Mouse Motor Synapses with the Necessary Participation of Sortilin and Adenosine A1-Receptors
AbstractBrain neurotrophin (BDNF) is synthesized by proteolysis of proneurotrophin to form mature BDNF and the prodomain, whose regulatory activity...
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Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder featured by abnormal movements, arising from the extensive neuronal...
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Stable and efficient expression of human brain-derived neurotrophic factor in tobacco chloroplasts
BackgroundBrain-derived neurotrophic factor (BDNF) is an intensively studied neurotrophin that promotes various physiological processes, such as...
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Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly...
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The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility
Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis,...
