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Mouse Genetics Methods and Protocols
This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are...
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Mouse Genetics and Breeding
The laboratory mouse (Mus musculus) has been employed in biomedical research for its amenability to genetic modification. The genetic modifications...
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Population genetics and demography of the endemic mouse species of Cyprus, Mus cypriacus
Mus cypriacus is one of three small palaeoendemic mammals that have survived the Mediterranean islands’ anthropization. This species, endemic to...
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Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal genetic heart disease characterized by cardiac arrhythmias, in which fibrofatty...
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Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific
The Asian Mouse Mutagenesis Resource Association (AMMRA) is a non-profit organization consisting of major resource and research institutions with...
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Loss-of-Function Mutagenesis for Forward Genetics
Genes are central players regulating biological processes. A general strategy for studying gene function is to impair gene activity and examine its...
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Systems genetics analysis of oral squamous cell carcinoma susceptibility using the mouse model: current position and new perspective
Oral squamous cell carcinoma (OSCC) is one of the most common human malignancies with complex etiology and poor prognosis. Although environmental...
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Fundamentals of Genetics
Genetics is a dynamic and rapidly advancing field of biology that has found applications in all dimensions of human life. Breakthrough genetic...
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Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine
AbstractTumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system....
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Maghrebian Mouse-Eared Bat Myotis punicus Felten, 1977
This comprehensive species-specific chapter covers all aspects of the mammalian biology, including paleontology, physiology, genetics, reproduction...
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Greater Mouse-Eared Bat Myotis myotis (Borkhausen, 1797)
This comprehensive species-specific chapter covers all aspects of the mammalian biology, including paleontology, physiology, genetics, reproduction...
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Generation of GM130 Conditional Knockout Mouse
The Golgi apparatus is a common and highly dynamic organelle in eukaryotic cells. It plays an important role in secretory trafficking and cargo...
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Lesser Mouse-Eared Bat Myotis blythii (Tomes, 1857)
This comprehensive species-specific chapter covers all aspects of the mammalian biology, including paleontology, physiology, genetics, reproduction...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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Prototype mouse models for researching SEND-based mRNA delivery and gene therapy
One of the major challenges of gene therapy—an approach to treat diseases caused by faulty genes—is a lack of technologies that deliver healthy gene...
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The molecular genetics of human appendicular skeleton
Disorders that result from de-arrangement of growth, development and/or differentiation of the appendages (limbs and digit) are collectively called...
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Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus
Morbilliviruses are among the most contagious viral pathogens of mammals. Although previous metagenomic surveys have identified morbillivirus...
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Gene Editing in Mouse Zygotes Using the CRISPR/Cas9 System
Engineering of the mouse germline is a key technology in biomedical research for studying the function of genes in health and disease. Since the...
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Techniques of Molecular Genetics
In advanced molecular biology and genetics, recombinant DNA technology appears as a boon that facilitates and opens up new challenges in the age of...
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Developmental Genetics
The foundation of the genetic approach to understand the development of an organism is that all the information is already encoded in an organism’s...