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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and...
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Fungal carboxylate transporters: recent manipulations and applications
AbstractCarboxylic acids containing acidic groups with additional keto/hydroxyl-groups or unsaturated bond have displayed great applicability in the...
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dMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor growth
Tumor cells have an increased demand for nutrients to sustain their growth, but how these increased metabolic needs are ensured or how this...
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Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors
Synthetic anticancer catalysts offer potential for low-dose therapy and the targeting of biochemical pathways in novel ways. Chiral organo-osmium...
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Disturbed Level of Lactate Transporters in Brain Cells during Acute Toxic Effect of β-Amyloid In Vitro and In Vivo
AbstractDecreased brain energy metabolism correlates with cognitive impairment in Alzheimer’s disease. There is accumulating experimental evidence...
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LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis
The epithelial-mesenchymal transformation (EMT) process of alveolar epithelial cells is recognized as involved in the development of pulmonary...
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The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles
The research literature suggests that different training modalities cause various patterns in training-induced genes expression. This study aimed to...
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The role of SLC transporters for brain health and disease
The brain exchanges nutrients and small molecules with blood via the blood–brain barrier (BBB). Approximately 20% energy intake for the body is...
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ATP-binding cassette (ABC) drug transporters in the develo** blood–brain barrier: role in fetal brain protection
The blood–brain barrier (BBB) provides essential neuroprotection from environmental toxins and xenobiotics, through high expression of drug efflux...
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Monocarboxylate transporter 9 (MCT9) is down‐regulated in renal cell carcinoma
BackgroundThe renal cell carcinoma (RCC) incidences are continuously increasing, however, their proper characterization remains difficult. Mammalian...
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The rete mirabile: a possible control site for swimbladder function
In a recent study, a large number of transport proteins was detected in the transcriptome and proteome of saline perfused rete mirabile tissue of the...
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An in vitro Study of the Effect of Bacterial Lipopolysaccharide on Transcription Levels of SLC Family Transporter Genes in Microglia
AbstractNeurodegenerative diseases are accompanied by neuroinflammation and excitotoxicity, in which microglia and astrocytes play an important role....
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Comparative transcriptome analysis unravels the response mechanisms of Cytospora mali QH2 to a biocontrol agent, Bacillus velezensis L-1
Bacillus velezensis L-1 was identified as an effective biocontrol agent against various postharvest fruit pathogens in previous work. However, little...
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The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM
Organic anion transporters (OATs) of the SLC22 family have crucial roles in the transport of organic anions, including metabolites and therapeutic...
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Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4)
Human monocarboxylate transporters (hMCTs/SLC16As) mediate the transport of monocarboxylic compounds across plasma membranes. Among the hMCTs, hMCT1...
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Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila ...
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SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma
Tumour cells mainly generate energy from glycolysis, which is commonly coupled with lactate production even under normoxic conditions. As a critical...
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Short-chain fatty acids in diseases
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The...
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Clinical relevance of glycosylation in triple negative breast cancer: a review
Glycosylation alterations in TNBC have significant implications for tumor behavior, diagnosis, prognosis, and therapeutic strategies. Dysregulated...
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Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
Genome-wide association studies have identified SLC16A13 as a novel susceptibility gene for type 2 diabetes. The SLC16A13 gene encodes...
