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Retinoblastoma cell-derived exosomes promote angiogenesis of human vesicle endothelial cells through microRNA‐92a-3p
Exosomes derived from tumor cells play a key role in tumor development. In the present study, we identified the bioactivity of exosomes released from...
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mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway
Pulmonary fibrosis (PF) is a chronic lung disorder, in which the mechanism of mmu-microRNA (miR)-92a-3p is not elucidated clearly. The present work...
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Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib
Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival rate following metastasis onset. Nerve growth factor (NGF) has...
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Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility
Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and attain functional maturation post-birth to...
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Altered expression of microRNAs in the rat diaphragm in a model of ventilator-induced diaphragm dysfunction after controlled mechanical ventilation
BackgroundVentilator-induced diaphragm dysfunction (VIDD) is a common complication of life support by mechanical ventilation observed in critical...
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Exosomes as Vascular Biomarkers for Diabetic Heart Disease and Diabetic Nephropathy
Exosomes are microvesicles that constitute a non-classical mechanism for protein secretion, and they represent a sub-proteome, thus assisting in the...
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The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling
Early studies indicated that the androgen receptor (AR) might play important roles in the regulating of the initiation and progression of...
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Non-coding RNAs and angiogenesis in cardiovascular diseases: a comprehensive review
Non-coding RNAs (ncRNAs) have key roles in the etiology of many illnesses, including heart failure, myocardial infarction, stroke, and in...
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Exosomes as Vascular Biomarkers for Diabetic Heart Disease and Diabetic Nephropathy
Exosomes are microvesicles that constitute a non-classical mechanism for protein secretion, and they represent a sub-proteome, thus assisting in the...
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miR-92a-3p regulates cisplatin-induced cancer cell death
Non-small cell lung cancer is characterized by a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Therefore,...
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Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients
AbstractThe transcriptional activity of genes encoding cancer/testis antigens (CTA) and its regulation in colorectal cancer (CRC) is not well...
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Blood-based microRNA profiling unveils complex molecular dynamics in breast cancer
BackgroundBreast cancer, a genetically intricate disease with diverse subtypes, exhibits heightened incidence globally. In this study, we aimed to...
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Using CRISPR/Cas9 to Edit a Thyroid Cancer Cell Line
Thyroid cancer is the most prevalent endocrine malignancy, comprising multiple types of cancer, with distinct clinical-pathological characteristics....
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Epigenetic Alterations in Colorectal Cancer
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the hallmarks of cancer and a fundamental trait of virtually all...
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iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
Recently, we reported that forkhead box A2 (FOXA2) is required for the development of human pancreatic α- and β-cells. However, whether miRNAs play a...
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Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy
BackgroundKidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed...
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Programmable Ultrasensitive Molecular Amplifier for Digital and Multiplex MicroRNA Quantification
Digital bioassays, popularized by digital PCR, provide some of the most robust and accurate methods for nucleic acid quantification. In this chapter,...
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Milk exosomal microRNA profiling identified miR-375 and miR-199-5p for regulation of immune response during subclinical mastitis of crossbred cattle
BackgroundThe dairy industry has experienced significant economic losses as a result of mastitis, an inflammatory disease of cows, including both...
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Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress
BackgroundThe mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to...
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Mutual regulation of PD-L1 immunosuppression between tumor-associated macrophages and tumor cells: a critical role for exosomes
Tumor cells primarily employ the PD-1/PD-L1 pathway to thwart the anti-tumor capabilities of T lymphocytes, inducing immunosuppression. This occurs...
