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Annexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway
Annexin A2 (ANXA2) is a widely reported oncogene. However, the mechanism of ANXA2 in esophageal cancer is not fully understood. In this study, we...
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The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor...
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Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy
AbstractAutism spectrum disorder (ASD) is a developmental disorder characterized by the early onset of problems with communication, learning, and...
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Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer
RB transcriptional corepressor 1 ( RB ) deletion is the most important genomic factor associated with the prognosis of castration-resistant prostate...
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Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling pathway is a vital...
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Investigation of the mutual crosstalk between ER stress and PI3K/AKT/mTOR signaling pathway in iron overload-induced liver injury in chicks
Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims...
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Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway
BackgroundRestoring impaired peripheral immune tolerance is the primary challenge in treating autoimmune diseases. Our previous research demonstrated...
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The m6A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway
Herein, we investigated the role of the m 6 A methylation enzyme METTL14 in regulating myocardial ischemia/reperfusion injury (IR/I) through the...
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USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway
BackgroundWith the rapidly increasing morbidity and mortality, lung cancer has been considered one of the serious malignant tumors, affecting...
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Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway
BackgroundNF-κB activating protein (NKAP) acts as a transcriptional suppressor in the Notch signaling pathway, It plays a role in hematopoiesis...
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Polyploidy and mTOR signaling: a possible molecular link
Polyploidy is typically described as the condition wherein a cell or organism has more than two complete sets of chromosomes. Occurrence of...
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mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
BackgroundSepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown...
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Short-term Dietary Selenium Deficiency Induced Liver Fibrosis by Inhibiting the Akt/mTOR Signaling Pathway in Rats
The effects of short-term dietary selenium deficiency on the liver and protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway...
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IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells
BackgroundGlioma is the most common type of brain tumors and isocitrate dehydrogenase (IDH1) gene is the most prominent molecular marker about the...
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DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway
DIS3L2 degrades different types of RNAs in an exosome-independent manner including mRNAs and several types of non-coding RNAs. DIS3L2-mediated...
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Eicosapentaenoic acid (EPA) improves grass carp (Ctenopharyngodon idellus) muscle development and nutritive value by activating the mTOR signaling pathway
Skeletal muscle is the mainly edible part of fish. Eicosapentaenoic acid (EPA) is a crucial nutrient for fish. This study investigated the effect of...
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Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway
Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Chemoresistance leads to poor responses to conventional...
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CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway
Circular RNAs (CircRNAs) are key regulators in the development and progression of human cancers. However, the biological roles and mechanisms of...
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Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway
Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we...
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Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma
BackgroundAbnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an...
