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Analysis of sRNAs and Their mRNA Targets in Sinorhizobium meliloti: Focus on Half-Life Determination
Regulation of gene expression at the level of RNA and/or by regulatory RNA is an integral part of the regulatory circuits in all living cells. In...
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The genetic and biochemical determinants of mRNA degradation rates in mammals
BackgroundDegradation rate is a fundamental aspect of mRNA metabolism, and the factors governing it remain poorly characterized. Understanding the...
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MiREx: mRNA levels prediction from gene sequence and miRNA target knowledge
Messenger RNA (mRNA) has an essential role in the protein production process. Predicting mRNA expression levels accurately is crucial for...
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mRNA Vaccine Platform: mRNA Production and Delivery
Abstract—Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which...
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Investigation of sRNA-mRNA Interactions in Bacillus subtilis In Vivo
In this chapter, we describe in vivo methods for the analysis of interactions between an sRNA and its target mRNA in B. subtilis. All these methods...
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Tethered mRNA Amplifier: A Novel Approach to Increase Protein Expression
Posttranscriptional RNA modification has become a revolutionary clinical tool to improve the underlying condition in genetic disorders. The cell...
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mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-1273 and BNT162b2 displayed...
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METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
BackgroundStroke is a major medical problem, and novel therapeutic targets are urgently needed. This study investigates the protective role and...
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The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA....
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Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids
Lipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids....
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Unlocking the promise of mRNA therapeutics
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering...
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IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
BackgroundIGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and...
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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and...
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The forerunners and successful partnerships behind the BioNTech mRNA vaccine
The discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in...
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Immunocompetent Mice As a Model for Preclinical Studies of mRNA Vaccine Immunogenicity
AbstractConducting preclinical studies of mRNA vaccines is complicated by the lack of relevant animal models of the human immune system....
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miR-430 regulates zygotic mRNA during zebrafish embryogenesis
BackgroundEarly embryonic developmental programs are guided by the coordinated interplay between maternally inherited and zygotically manufactured...
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A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines
Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP) format could enhance vaccine access in low-resource communities...
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Atlas of mRNA translation and decay for bacteria
Regulation of messenger RNA stability is pivotal for programmed gene expression in bacteria and is achieved by a myriad of molecular mechanisms. By...
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GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability
Age-associated hypercoagulability is accompanied by the increase of plasma levels of some coagulation factors including fibrinogen which may...
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The Functions of N-methyladenosine (m6A) Modification on HIV-1 mRNA
In recent years, there has been a growing interest in the study of RNA modifications, with some researchers focusing specifically on the connection...
