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Lipid analysis of CO2-rich subsurface aquifers suggests an autotrophy-based deep biosphere with lysolipids enriched in CPR bacteria
Sediment-hosted CO 2 -rich aquifers deep below the Colorado Plateau (USA) contain a remarkable diversity of uncultivated microorganisms, including...
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The Role of Lipid Domains and Physical Properties of Membranes in the Development of Age-Related Neurodegenerative Diseases
AbstractA growing number of studies points to the relationship between the development of neurodegenerative diseases and the structure and lipid...
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A metabolic perspective of selection for fruit quality related to apple domestication and improvement
BackgroundApple is an economically important fruit crop. Changes in metabolism accompanying human-guided evolution can be revealed using a multiomics...
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Preparation of Giant Vesicles with Mixed Single-Tailed and Double-Tailed Lipids
Giant vesicles are model membrane systems that can be characterized with microscopy. Whereas most giant synthetic vesicles are created with a single...
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Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers
Background and aimsTwo of the most lethal gastrointestinal (GI) cancers, gastric cancer (GC) and colon cancer (CC), are ranked in the top five...
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Physico-Chemical Mechanisms of the Functioning of Membrane-Active Proteins of Enveloped Viruses
AbstractOver the past few years, the attention of the whole world has been riveted to the emergence of new dangerous strains of viruses, among which...
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Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways
Macropinocytosis is an evolutionarily conserved endocytic pathway that mediates the nonselective acquisition of extracellular material via large...
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The Influence of Endophyte Laminariocolax aecidioides (Rosenvinge) A.F. Peters, 1998 (Phaeophyceae, Ectocarpales) on the Lipid Composition of the Brown Alga Undaria pinnatifida (Harvey) Suringar, 1873 (Phaeophyceae: Laminariales)
AbstractThe composition of polar lipid classes and the composition of fatty acids of neutral and polar lipid fractions were studied in tissues of the...
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Phospholipase A2. Methods for Activity Monitoring
Abstract —Phospholipases A2 (PLA2) are hydrolytic proteins, which cleave fatty acid off the second position ( sn- 2) of the phospholipid. An increased...
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The effects of real and simulated microgravity on cellular mitochondrial function
Astronauts returning from space shuttle missions or the International Space Station have been diagnosed with various health problems such as bone...
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Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide leading to 31% of all global deaths. Early prediction and...
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Non-Phosphorus Lipids As New Antitumor Drug Prototypes
AbstractThe main classes of antitumor drugs (antimetabolites, anthracyclines, taxanes, and alkylating agents) act via DNA damage, inhibit DNA...
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Estimation of the Phospholipase A2 Selectivity on POPC/POPG Membranes Using the Interaction Map
AbstractThe regulation of the activity and selectivity of phospholipase A2 (PLA2), which is capable of cleaving fatty acid in the second position ( sn-2...
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A novel and diverse group of Candidatus Patescibacteria from bathypelagic Lake Baikal revealed through long-read metagenomics
BackgroundLake Baikal, the world’s deepest freshwater lake, contains important numbers of Candidatus Patescibacteria (formerly CPR) in its deepest...
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Lipid and Lipidation in Membrane Fusion
Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion...
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3 Biogenesis and cellular dynamics of glycerophospholipids in the yeast Saccharomyces cerevisiae
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, glycerophospholipids are important cellular components required for growth and cell...
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Genetic and molecular basis of carotenoid metabolism in cereals
Carotenoids are vital pigments for higher plants and play a crucial function in photosynthesis and photoprotection. Carotenoids are precursors of...
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Prevention, Diagnosis, and Understanding Mechanisms of Metabolic Diseases Using Systems Biology
Human metabolic diseases are typically network diseases. These diseases including cardiovascular diseases (CVDs), type 2 diabetes (T2D), obesity,...
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Association analysis of germination level cold stress tolerance and candidate gene identification in Upland cotton (Gossypium hirsutum L.)
Cotton originated from ancestors in the Gossypium genus that grew in semi-desert habitats. As a result, it is adversely affected by low temperatures...
