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Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain...
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Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in...
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S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
BackgroundCigarette smoke-induced chronic airway inflammation increases the risk of lung cancer and plays a multifaceted role in lung cancer...
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Genomic attributes of airway commensal bacteria and mucosa
Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors....
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Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Gasdermin (GSDM) family, the key executioners of pyroptosis, play crucial roles in anti-pathogen and anti-tumor immunities, although little is known...
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Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in...
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The gut–airway microbiome axis in health and respiratory diseases
Communication between the gut and remote organs, such as the brain or the cardiovascular system, has been well established and recent studies provide...
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Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model
Emerging evidence demonstrates that pyroptosis has been implicated in the pathogenesis of asthma. Gasdermin D (GSDMD) is the pyroptosis executioner....
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Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation
BackgroundsAllergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study...
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PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation
Polymerase 1 and transcript release factor (PTRF, encoding by Cavin-1 ) regulates interleukin 33 (IL-33) release, which is implicated in asthma...
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Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway...
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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM2.5-aggravated COPD airway remodeling by enhancing myofibroblast differentiation
Emphysema, myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution, especially fine...
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Establishing Air-Liquid Interface (ALI) Airway Culture Models for Infectious Disease Research
Air-liquid interface (ALI) airway cultureAir-liquid interface (ALI) airway culture models serve as a powerful tool to emulate the characteristic...
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Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma
Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling,...
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CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation
Ovarian tumor family deubiquitinase 4 (OTUD4), a member of the OTU deubiquitinating enzyme, is implicated to decrease in cancer to regulate cell...
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Multi-omics in Study of Lung Microbiome
The lung microbiome influences the pathophysiology of pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic...
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Culture and expansion of murine proximal airway basal stem cells
BackgroundThe stem cell characteristic makes basal cells desirable for ex vivo modeling of airway diseases. However, to date, approaches allowing...
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Introduction to Lung Disease
There has been a rise in the number of documented instances of lung illness in both children and adults around the globe. Both the morbidity and...
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The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell–derived lung progenitors in 3D
Lung and airway epithelial cells generated in vitro from human pluripotent stem cells (hPSCs) have applications in regenerative medicine, modeling of...
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Roles of pulmonary telocytes in airway epithelia to benefit experimental acute lung injury through production of telocyte-driven mediators and exosomes
BackgroundTelocytes (TCs) are experimentally evidenced as an alternative of cell therapies for organ tissue injury and repair. The aims of the...
