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Update on Brazilian essential oils with leishmanicidal activity
Leishmaniasis are neglected diseases caused by protozoan parasites and have been mainly related to climate change, poverty, malnutrition, and the...
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In vitro leishmanicidal activity of two cholesterol derivatives
We evaluated the leishmanicidal activity of commercially available 5α-cholest-7-en-3β-ol [5α-chol], (+)-4-cholesten-3-one [(+)-4-chol] and the...
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Antiparasitic activity and cytotoxic potential of the hydroethanolic extract the leaves of Tocoyena formosa
Chagas disease and leishmaniasis are considered severe public health problems and are part of the group of neglected tropical diseases. To find new...
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The Therapeutic Effects of Curcumin-coated Gold Nanoparticle Against Leishmania Major Causative Agent of Zoonotic Cutaneous Leishmaniasis (ZCL): An In Vitro and In Vivo Study
We synthesized and characterized curcumin-coated gold nanoparticles (Cur@AuNPs) and investigated their stability, cytotoxicity, leishmanicidal...
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Brazilian arnicas: bioactive compounds, pharmacological properties, potential use and clinical applications
Brazilian arnicas belong to the Asteraceae family and can be mainly found in the Brazilian biome Cerrado (savanna) but also Caatinga, Atlantic...
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Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores
In the constant search for new pharmacological compounds, molecular hybridisation is a well-known technique whereby two or more known pharmacophoric...
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The Potential Role of Lipopeptide Biosurfactant Generated by Acinetobacter junii B6 on Leishmania Tropica: The Synergy of Lipopeptide Biosurfactant and Glucantime
An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB) produced by Acinetobacter junii B6 affects Leishmania...
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Occurrence, identification and characterization of diazotrophic bacteria from aerial roots of Rhynchostylis retusa (L.) Blume for plant growth-promoting activity
In this study, the diversity of diazotrophic bacteria of orchid Rhynchostylis retusa (L.) Blume and its potential application in plant growth...
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Exploring Endoperoxides as Leishmanicidal Compounds
With advances in genomics, proteomics, and bioinformatics, identification of unique parasite-specific metabolic pathways has facilitated development...
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Synthesis and characterization of zinc derivatized 3, 5-dihydroxy 4′, 7-dimethoxyflavone and its anti leishmaniasis activity against Leishmania donovani
This study reports the synthesis and characterization of zinc derivatized 3,5-dihydroxy 4′, 7- dimethoxyflavone (DHDM-Zn) compound for the...
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Chemistry, Biological Activity, and Uses of Clusia Latex
Plants of the genus Clusia L. have had considerable importance to numerous traditional communities, providing food, remedies, and raw materials for...
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Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights
Emergence of antimicrobial resistance has become a great threat to human species as there is shortage of development of new antimicrobial agents. So,...
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Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent
Changes in host immunity and parasite resistance to drugs are among the factors that contribute to decreased efficacy of antiparasitic drugs such as...
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Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol
The aim of this study was to evaluate the antioxidant, antibacterial, and antibiofilm activities of nerolidol. The antioxidant activity of nerolidol...
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In vitro leishmanicidal activity and theoretical insights into biological action of ruthenium(II) organometallic complexes containing anti-inflammatories
Leishmaniasis, a neglected tropical disease caused by protozoans of the genus Leishmania , kills around 20–30 thousand people in Africa, Asia, and...
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Antioxidant and Antileishmanial Activities, and Evaluation of Acute Oral Toxicity and Genotoxicity of Bixa orellana Leaf Extracts
Herein, we determined the phytochemical profile and antioxidant and antileishmanial activities of aqueous, saline, and hydroethanolic extracts (AE,...
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Antimicrobial, antioxidant and antileishmanial activities of Ziziphus lotus leaves
The aim of this study was to investigate antimicrobial and antioxidant activities of different fractions obtained from edible Tunisian Ziziphus Lotus ...
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Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Snake venom L-amino acid oxidases (LAAOs) are flavoenzymes with diverse physiological and pharmacological effects. These enzymes are found to...
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Partial characterization of purified glycoprotein from nutshell of Arachis hypogea L. towards macrophage activation and leishmaniacidal activity
Arachis hypogea L. protein fraction-2 (AHP-F2) from the Peanut shell was extracted and characterized and its potent immunomodulatory and...
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Essential Oils of Baccharis: Chemical Composition and Biological Activities
This chapter provides a review of the characteristics of essential oils of Baccharis species with special emphasis on their chemical composition and...