Search
Search Results
-
The virome of the last eukaryotic common ancestor and eukaryogenesis
All extant eukaryotes descend from the last eukaryotic common ancestor (LECA), which is thought to have featured complex cellular organization. To...
-
Reconstruction of the last bacterial common ancestor from 183 pangenomes reveals a versatile ancient core genome
BackgroundCumulative sequencing efforts have yielded enough genomes to construct pangenomes for dozens of bacterial species and elucidate...
-
Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components
Over millions of years, eukaryotes evolved from unicellular to multicellular organisms with increasingly complex genomes and sophisticated gene...
-
Origins and Functional Significance of Eukaryotic Protein Folds
Folds are the architecture and topology of a protein domain. Categories of folds are very few compared to the astronomical number of sequences....
-
The spread of the first introns in proto-eukaryotic paralogs
Spliceosomal introns are a unique feature of eukaryotic genes. Previous studies have established that many introns were present in the protein-coding...
-
Self-assembling viral histones are evolutionary intermediates between archaeal and eukaryotic nucleosomes
Nucleosomes are DNA–protein complexes composed of histone proteins that form the basis of eukaryotic chromatin. The nucleosome was a key innovation...
-
On Protein Loops, Prior Molecular States and Common Ancestors of Life
The principle of continuity demands the existence of prior molecular states and common ancestors responsible for extant macromolecular structure....
-
A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution
Histones and associated chromatin proteins have essential functions in eukaryotic genome organization and regulation. Despite this fundamental role...
-
Concepts of the last eukaryotic common ancestor
Insight into the last eukaryotic common ancestor (LECA) is central to any phylogeny-based reconstruction of early eukaryotic evolution. Increasing...
-
Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding
It is now widely accepted that the first eukaryotic cell emerged from a merger of an archaeal host cell and an alphaproteobacterium. However, the...
-
Global patterns and rates of habitat transitions across the eukaryotic tree of life
The successful colonization of new habitats has played a fundamental role during the evolution of life. Salinity is one of the strongest barriers for...
-
Conservation and similarity of bacterial and eukaryotic innate immunity
Pathogens are ubiquitous and a constant threat to their hosts, which has led to the evolution of sophisticated immune systems in bacteria, archaea...
-
Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold
Evolutionary arms races between cells and viruses drive the rapid diversification of antiviral genes in diverse life forms. Recent discoveries have...
-
Discovery and Study of Transmembrane Rotary Ion-Translocating Nano-Motors: F-ATPase/Synthase of Mitochondria/Bacteria and V-ATPase of Eukaryotic Cells
AbstractThis review discusses the history of discovery and study of the operation of the two rotary ion-translocating ATPase nano-motors: (i)...
-
Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1
Polycomb group proteins, as part of the Polycomb repressive complexes, are essential in gene repression through chromatin compaction by canonical...
-
Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis
Charting the emergence of eukaryotic traits is important for understanding the characteristics of organisms that contributed to eukaryogenesis....
-
Reconstruction of hundreds of reference ancestral genomes across the eukaryotic kingdom
Ancestral sequence reconstruction is a fundamental aspect of molecular evolution studies and can trace small-scale sequence modifications through the...
-
Evolution: Mitochondrial Ribosomes Across Species
The ribosome is among the most complex and ancient cellular macromolecular assemblies that plays a central role in protein biosynthesis in all living...
-
Revisiting biocrystallization: purine crystalline inclusions are widespread in eukaryotes
Despite the widespread occurrence of intracellular crystalline inclusions in unicellular eukaryotes, scant attention has been paid to their...
-
Genetics re-establish the utility of 2-methylhopanes as cyanobacterial biomarkers before 750 million years ago
Fossilized lipids offer a rare glimpse into ancient ecosystems. 2-Methylhopanes in sedimentary rocks were once used to infer the importance of...
