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Integrins in Health and Disease Key Effectors of Cell-Matrix and Cell-Cell Interactions
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They...
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Integrins and their potential roles in mammalian pregnancy
Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and...
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Integrins as the pivotal regulators of cisplatin response in tumor cells
Cisplatin (CDDP) is a widely used first-line chemotherapeutic drug in various cancers. However, CDDP resistance is frequently observed in cancer...
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α4 Integrins in Immune Homeostasis and Disease
α4 integrins (including α4β1 and α4β7) are primarily expressed on leukocytes. By interacting with their ligands expressed on high endothelial venules...
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Structural analysis of peptide binding to integrins for cancer detection and treatment
Integrins are cell receptors involved in several metabolic pathways often associated with cell proliferation. Some of these integrins are...
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Integrins in Cardiac Form, Function, and Disease
Integrins are cell surface receptors expressed ubiquitously including on cardiac cells, which are critical for maintaining homeostasis in the...
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Integrins as Receptors for Bacterial and Viral Pathogens
Integrins are important cell surface receptors named cell adhesion molecules that mediate cell–cell, cell–matrix, and cell–pathogen interactions....
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Integrins in Pathological Tissue Remodelling of Joints
Osteoarthritis (OA), a primarily degenerative disorder, and rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease, belong to the most...
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Integrins: Key Targets in Tissue Fibrosis and Tumor Stroma
Fibrosis, the hallmark of the excessive deposition of extracellular matrix (ECM), is the response of the body to tissue injury. The tissue matrix...
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Integrins α1β1 and α2β1: The Generalist Collagen Receptors
Four members of the large integrin family have the capability to directly recognize specific collagenous motifs in proteins. These integrins can be...
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Platelet Integrins: Critical Mediators of Haemostasis and Pathological Thrombus Formation
Platelets are small anucleated blood cells that survey the integrity of the blood vasculature, ready to rapidly seal injuries in order to limit blood...
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Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis
Controlled exocytosis and endocytosis of integrin adhesion receptors is required for normal cell adhesion, migration, and signaling. In this chapter,...
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Pathways of integrins in the endo-lysosomal system
In this review, we present recent scientific advances about integrin trafficking in the endo-lysosomal system. In the last few years, plenty of new...
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β2-integrins in Immunity: New Roles for Old Players
β2-integrins are adhesion- and mechanoreceptors expressed exclusively on leukocytes. They mediate diverse functions in immunity and are of...
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Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals
Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a chemical response. Integrins are involved in the...
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Talin and kindlin use integrin tail allostery and direct binding to activate integrins
Integrin affinity regulation, also termed integrin activation, is essential for metazoan life. Although talin and kindlin binding to the β-integrin...
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α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions
BackgroundKeratinocytes form the main protective barrier in the skin to separate the underlying tissue from the external environment. In order to...
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Influence of integrins on thrombus formation: a road leading to the unravelling of DVT
Integrins are a group of transmembrane glycoprotein receptors that are responsible for platelet activation through bidirectional signalling. These...
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Biologia Futura: stories about the functions of β2-integrins in human phagocytes
Integrins are essential membrane proteins that provide a tightly regulated link between the extracellular matrix and the intracellular cytoskeletal...
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Do tumor exosome integrins alone determine organotropic metastasis?
Metastasis is the most life-threatening event in cancer patients, so the key strategy to treat cancer should be preventing tumor spread. Predicting...
