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Epigenetic Mechanisms in Inflammation
Epigenetic modifications are triggered by environmental changes and play a critical role in how genes are expressed in response to stimuli. The...
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Fatty Acids and their Proteins in Adipose Tissue Inflammation
Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of...
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Guggulsterone protects against cigarette smoke-induced COPD linked lung inflammation
Recently, we have shown that guggulsterone is the principal constituent responsible for protective effects of Commiphora wightii against...
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Protein–Protein Interactions in Immune Disorders and Inflammation
Immune system disorders arise when the immune system is either over-activated or depressed. Autoimmune disorders that affect millions of people...
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Exploring redox imbalance and inflammation for asthma therapy
Background:Asthma is a prolonged inflammatory disorder of the airways, that affects an estimated 300 million people worldwide. Asthma is triggered by...
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Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging
Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive...
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Inflammation and Cancer: Role of Tight Junctions
Tight junctions are critical for the homeostatic maintenance of epithelial barrier integrity, especially in the gastrointestinal tract. In addition,...
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Modulation of serotonin transporter expression by escitalopram under inflammation
Selective serotonin reuptake inhibitors (SSRIs) are widely used for depression based on the monoamine deficiency hypothesis. However, the clinical...
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Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation
BackgroundsAllergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study...
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Mitochondria and cell death-associated inflammation
Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during...
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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces...
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Systemic inflammation and biological aging in the Health and Retirement Study
Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk factor for several chronic diseases and mortality. Using...
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Clearance of apoptotic cells by neutrophils in inflammation and cancer
When a cell dies of apoptosis, it is eliminated either by neighbouring cells or by attracted professional phagocytes. Although it was generally...
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Thrombin in the Crossroad Hemostasis and Inflammation
AbstractHemostasis and immune responses are evolutionarily and functionally related systems on the coordinated work of which vital...
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Diagnostic and therapeutic value of EVs in lungs diseases and inflammation
Extracellular vesicles (EVs) are membrane-derived messengers which have been playing an important role in the inflammation and pathogenesis of lung...
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The NLRP3 inflammasome: contributions to inflammation-related diseases
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the...
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Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells
Disruption of circadian rhythm during pregnancy produces adverse health outcomes in offspring; however, the role of maternal circadian rhythms in the...
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Metabolic Adaptations and Functional Activity of Macrophages in Homeostasis and Inflammation
AbstractIn recent years, the role of cellular metabolism in immunity has come into the focus of many studies. These processes form a basis for the...
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The link between the gut microbiome, inflammation, and Parkinson’s disease
AbstractAs our society ages, the growing number of people with Parkinson’s disease (PD) puts tremendous pressure on our society. Currently, there is...
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Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model
Emerging evidence demonstrates that pyroptosis has been implicated in the pathogenesis of asthma. Gasdermin D (GSDMD) is the pyroptosis executioner....
