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Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart...
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings
Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood...
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Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient...
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Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis
Purpose of ReviewAdult human hematopoiesis resides in the bone marrow (BM), which is comprised of multiple niches capable of supporting...
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Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment
BackgroundCD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute...
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Clonal hematopoiesis in cardiovascular disease and therapeutic implications
Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to hematopoietic stem cells and the outgrowth of clones of blood...
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Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate
Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in hematopoietic stem cells confer a selective advantage and drive...
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Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies
Bone marrow adipose tissue (BMAT) creates a specific microniche within multifunctional bone marrow (BM) ecosystem which imposes changes in...
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Extramedullary hematopoiesis: mesenchymal stromal cells from spleen provide an in vitro niche for myelopoiesis
Murine spleen has been shown to harbour stromal cells that support hematopoiesis with production of myeloid antigen–presenting cells. Similar stromal...
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Cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and associates with worse prognosis...
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The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution
Elevated extrachromosomal circular DNA (eccDNA) has been reported to accelerate tumor pathogenesis. Although the eccDNA profiles of other tumors have...
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A new risk factor associated with cardiovascular disease: clonal hematopoiesis of indeterminate potential
Clonal hematopoiesis is a prevalent disease associated with all-cause death. Not only because it can be a precancerous lesion of blood system...
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Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity – A Journey to the Developmental Roots
A cell's most significant existential task is to survive by ensuring proper metabolism, avoiding harmful stimuli, and adapting to changing...
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WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis
The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates...
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Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
With planned deep space and commercial spaceflights, gaps remain to address health risks in astronauts. Multiple studies have shown associations...
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Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis
Clonal hematopoiesis (CH) increases the risk of atherosclerotic cardiovascular disease possibly due to increased plaque inflammation. Human studies...
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Hypoxia drives hematopoiesis with the enhancement of T lineage through eliciting arterial specification of hematopoietic endothelial progenitors from hESC
BackgroundHematopoietic stem cells are able to self-renew and differentiate into all blood cell lineages. Hematopoietic stem cell transplantation is...
