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Sulbactam protects neurons against double neurotoxicity of amyloid beta and glutamate load by upregulating glial glutamate transporter 1
Amyloid beta (Abeta) synergistically enhances excitotoxicity of glutamate load by impairing glutamate transporter 1 (GLT1) expression and function,...
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Urolithin B protects PC12 cells against glutamate-induced toxicity
BackgroundThe involvement of malfunctioning glutamate systems in various central nervous system (CNS) disorders is widely acknowledged. Urolithin B,...
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Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity
Abstract —Parkinson’s disease is associated with neuronal loss in the midbrain and the resulting development of dopamine-deficient states. At the...
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BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons
BackgroundGlutamate exposure was fatal to HT-22 neuronal cells that derived from mouse hippocampus. This is often used as a model for hippocampus...
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Kinetic fingerprinting of metabotropic glutamate receptors
Dimeric metabotropic glutamate receptors (mGluRs) are abundantly expressed in neurons. In mammals, eight subunit isoforms, mGluR1-8, have been...
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Glutamate production from aerial nitrogen using the nitrogen-fixing bacterium Klebsiella oxytoca
Glutamate is an essential biological compound produced for various therapeutic and nutritional applications. The current glutamate production process...
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Glutamate and GABA Receptors of Nerveless Animals (Placozoa): Preadaptation to Neurotransmission
Abstract —The emergence of the nervous system is one of the most important events in the evolution of life on Earth. The details of this event remain...
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Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy
Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD...
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An in vitro study on the stimulatory effects of extracellular glutamate on astrocytes
BackgroundIn our previous research, it was found that the cerebrospinal fluid had higher levels of glutamate, astrocytes were stimulated and released...
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Induction of glioblastoma invasion triggered by system Xc−-mediated glutamate release
BackgroundsGlioblastoma (GBM) is a highly aggressive brain cancer associated with poor prognosis, primarily attributed to its profound invasive...
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Glycogen deficiency enhances carbon partitioning into glutamate for an alternative extracellular metabolic sink in cyanobacteria
Glycogen serves as a metabolic sink in cyanobacteria. Glycogen deficiency causes the extracellular release of distinctive metabolites such as...
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Metabolic engineering of Shewanella oneidensis to produce glutamate and itaconic acid
AbstractShewanella oneidensis is a gram-negative bacterium known for its unique respiratory capabilities, which allow it to utilize a wide range of...
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Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy
CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living...
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Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission
The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with genetic and molecular specificity. However, existing iGluSnFR...
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Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development
AbstractGABA and glutamate are the most abundant neurotransmitters in the CNS and play a pivotal part in synaptic stability/plasticity. Glutamate and...
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Evidence for transporter-mediated uptake of environmental l-glutamate in a freshwater sponge, Ephydatia muelleri
The freshwater sponge, Ephydatia muelleri, lacks a nervous or endocrine system and yet it exhibits a coordinated whole-body action known as a...
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Evolutionary and functional analysis of metabotropic glutamate receptors in lampreys
The metabotropic glutamate receptor (mGluR, GRM) family is involved in multiple signaling pathways and regulates neurotransmitter release. However,...
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Lack of Glutamate Synthase in Streptococcus zooepidemicus makes a Natural Driving Force for Increasing Hyaluronic Acid Production
Hyaluronic acid (HA) has many applications in the pharmaceutical and cosmetic industries. Streptococcus zooepidemicus is naturally producing HA with...
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Effects of Quercetin on Ovarian Toxicity Induced by Dietary Monosodium Glutamate
AbstractMonosodium glutamate (MSG) is globally used to impart flavor in cooking and to improve palatability. This work assessed the protective...
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Chlorogenic acid regulates the expression of protein phosphatase 2A subunit B in the cerebral cortex of a rat stroke model and glutamate-exposed neurons
BackgroundIschemic stroke is a serious neurological disorder caused by blockages in cerebral artery. Protein phosphatase 2A (PP2A) is a phosphatase...
