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Identification of Plant-Based Bio-Actives in the Treatment of Ulcerative Colitis Using Virtual Screening and In Vivo Approaches
Ulcerative colitis (UC) is a kind of persistent inflammatory bowel disease that is a root cause for lifelong soreness in the colon and rectum...
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Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology
SARS-CoV-2 is the foremost culprit of the novel coronavirus disease 2019 (nCoV-19 and/or simply COVID-19) and poses a threat to the continued life of...
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Recent advances in flavonoid compounds for the treatment of prostate cancer
Prostate cancer is a malignant epithelial tumor of the prostate gland and is the most common malignant tumor of the male genitourinary system....
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Prediction of Rab5B inhibitors through integrative in silico techniques
Rab5B is a small monomeric G protein that regulates early endocytosis and controls signaling pathways related to cell growth, survival, and...
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Secondary Metabolites Biosynthesis and Related Gene Expression Under Ultraviolet-B Radiation
Plants have a diverse array of secondary metabolites as part of their defense mechanism against various stress conditions. These secondary...
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Anticancer Properties of Pteridophytes and Derived Compounds: Pharmacological Perspectives and Medicinal Use
Pteridophytes are primitive vascular plants with sporophytic generation as a dominant phase. Moist and shady habitats are preferred for their...
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Anticancer Properties of Pteridophytes and Derived Compounds: Pharmacological Perspectives and Medicinal Use
Pteridophytes are primitive vascular plants with sporophytic generation as a dominant phase. Moist and shady habitats are preferred for their...
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Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
AbstractHepatocellular carcinoma (HCC) is the most common primary liver malignancy and poses a severe threat to human health. Ginkgo biloba leaf...
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Role of Polyphenols in Cardiovascular Diseases
The health advantages of polyphenols have been well documented in recent years, with particular focus on their protective effects against...
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Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing...
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Warming Increased Metabolite Composition and Pathways in Root Exudates of Chinese Fir Saplings in Subtropical China
Despite the important role of root exudates in the functions and processes of forest ecosystems, few studies have examined the effects of warming on...
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Functional stratification of cancer drugs through integrated network similarity
Drugs not only perturb their immediate protein targets but also modulate multiple signaling pathways. In this study, we explored networks modulated...
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Curative Potential of High-Value Phytochemicals on COVID-19 Infection
AbstractMedicinal plants and their therapeutically promising chemical compounds belonging to the valued category of ‘traditional medicine’ are...
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Identification of Mulberrofuran as a potent inhibitor of hepatitis A virus 3Cpro and RdRP enzymes through structure-based virtual screening, dynamics simulation, and DFT studies
Hepatitis is a medical condition characterized by inflammation of the liver. It is commonly caused by the hepatitis viruses A, B, C, D, and E....
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Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm
Biofilms are complex communities of microorganisms enclosed in a self-produced extracellular matrix, posing a significant threat to different...
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Exploring putative drug properties associated with TNF-alpha inhibition and identification of potential targets in cardiovascular disease using machine learning-assisted QSAR modeling and virtual reverse pharmacology approach
Cardiovascular disease is a chronic inflammatory disease with high mortality rates. TNF-alpha is pro-inflammatory and associated with the disease,...
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LC-MS metabolomics profiling of Salvia aegyptiaca L. and S. lanigera Poir. with the antimicrobial properties of their extracts
BackgroundSalvia L. (Lamiaceae) found in almost all countries in temperate and tropical regions. Both S. aegyptiaca L. and S. lanigera Poir. have a...
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Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways
Icariin is a primary active component of the traditional Chinese medicinal plant Epimedium grandiflorum. A range of pharmacological effects of...
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Bioprospecting of Plants for Phytochemicals: Important for Drugs
Bioprospecting is a multidisciplinary endeavor that entails systematic discovery, isolation, and identification of new bioactive molecules utilizing...