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Hax1 regulate focal adhesion dynamics through IQGAP1
Cell migration is a highly orchestrated process requiring the coordination between the cytoskeleton, cell membrane and extracellular matrix...
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Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here...
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Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes
AbstractFocal adhesions (FAs) are mechanosensory structures that transform physical stimuli into chemical signals guiding cell migration....
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Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase
We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of...
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FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion
Recurrence and metastasis are the main causes of breast cancer (BRCA)-related death and remain a challenge for treatment. In-depth research on the...
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Probing the ER-Focal Adhesion Link During Cell Migration
Focal adhesions (FAs) are contact points of the cell with the extracellular matrix (ECM) and play a major role in several cellular functions...
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RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation
BackgroundMetastasis is the leading cause of death among patients with colorectal cancer (CRC). Therefore, it is important to explore the molecular...
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LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR1), an immune receptor containing immunoreceptor tyrosine-based inhibiory motifs (ITIMs),...
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Testing the Role of Focal Adhesion Kinase (FAK) in Topography-Mediated Stem Cell Differentiation by Inhibiting FAK Phosphorylation
Stem cell differentiation can be modulated by the substrate topographies. Focal adhesion kinase (FAK) has been identified as a key regulator in...
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Adhesion, metastasis, and inhibition of cancer cells: a comprehensive review
This comprehensive review delves into cancer’s complexity, focusing on adhesion, metastasis, and inhibition. It explores the pivotal role of these...
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Focal Adhesion Isolation Assay Using ECM-Coated Magnetic Beads
Focal adhesions are force sensitive structures that dynamically alter their composition, protein-protein interactions, and signaling in response to...
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Ihog proteins contribute to integrin-mediated focal adhesions
Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved,...
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Computational Design of Peptides with Improved Recognition of the Focal Adhesion Kinase FAT Domain
We describe a two-stage computational protein design (CPD) methodology for the design of peptides binding to the FAT domain of the protein focal...
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The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility
Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis,...
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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma
Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response...
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CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation,...
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Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer
Pancreatic cancer (PC) is prone to distant metastasis in the early stage, which is attributed to the strong migration ability of tumor cells. Focal...
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MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly
Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours...
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Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals
During differentiation, skeletal muscle develops mature multinucleated muscle fibers, which could contract to exert force on a substrate. Muscle...
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Role of adhesion molecules in cancer and targeted therapy
Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them....