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Maternal Methyl-Enriched Diet Improves Episodic Memory but Does Not Affect Conditioned Fear Memory in Offspring of WAG/Rij Rats
AbstractThis study was aimed to find out what effect the maternal methyl-enriched diet (MED) in the perinatal period exerts on cognitive functions in...
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Peculiarities of Fear Memory Extinction in Male and Female Disc1-Q31L Mice
AbstractDepressive disorders are common psychopathologies highly comorbid with other mental diseases, especially post-traumatic stress disorder, with...
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The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation
The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet specific molecular pathways for neuronal ERK activation...
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Involvement of isoproterenol-induced intracellular Zn2+ dynamics in the basolateral amygdala in conditioned fear memory
Beta-adrenergic receptors in the basolateral amygdala play an essential role in fear memory, while the physiological role of intracellular Zn 2+ ...
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SALM4 negatively regulates NMDA receptor function and fear memory consolidation
Many synaptic adhesion molecules positively regulate synapse development and function, but relatively little is known about negative regulation....
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Exploration driven by a medial preoptic circuit facilitates fear extinction in mice
Repetitive exposure to fear-associated targets is a typical treatment for patients with panic or post-traumatic stress disorder (PTSD). The success...
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An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing...
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Fear extinction is impaired in aged rats
Normal aging is accompanied by broad loss of cognitive function in humans and rodents, including declines in cognitive flexibility. In extinction, a...
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Ecological analysis of Pavlovian fear conditioning in rats
Pavlovian fear conditioning, which offers the advantage of simplicity in both the control of conditional and unconditional stimuli (CS, US)...
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Effect of Nitric Oxide Synthase Inhibitors on Serotonin Release in Medial Prefrontal Cortex during Conditioned Fear Response Acquisition and Generalization in Rats
AbstractSerotonergic and nitrergic systems in the medial prefrontal cortex (mPFC) are involved in the control of fear generalization, but their local...
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EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory
Many brain diseases lead to a reduction in the number of functional neurons and it would be of value to be able to increase the number of neurons in...
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Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice
Histone variants H2A.Z and H3.3 are epigenetic regulators of memory, but roles of other variants are not well characterized. macroH2A (mH2A) is a...
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Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology
While impaired fear generalization is known to underlie a wide range of psychopathology, the extent to which exposure to trauma by itself results in...
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Ethanol’s impact on the brain: a neurobiological perspective on the mechanisms of memory impairment
Alcohol consumption is known to have detrimental effects on memory function, with various studies implicating ethanol in the impairment of cognitive...
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Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders
Estrogen regulates a wide range of neuronal functions in the brain, such as dendritic spine formation, remodeling of synaptic plasticity, cognition,...
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Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change
Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable...
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Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis
Post-traumatic stress disorder (PTSD) is a debilitating mental health condition for which current treatments have long-term efficacy in 50% of...
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Oligodendroglia are emerging players in several forms of learning and memory
Synaptic plasticity is the fundamental cellular mechanism of learning and memory, but recent research reveals that myelin-forming glia,...
