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The effect of eugenol anesthesia on the electric organ discharge of the weakly electric fish Apteronotus leptorhynchus
Eugenol, the major active ingredient of clove oil, is widely used for anesthesia in fish. Yet virtually nothing is known about its effects on CNS...
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A chromosome-level genome of electric catfish (Malapterurus electricus) provided new insights into order Siluriformes evolution
The electric catfish ( Malapterurus electricus ), belonging to the family Malapteruridae, order Siluriformes (Actinopterygii: Ostariophysi), is one of...
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The effect of urethane and MS-222 anesthesia on the electric organ discharge of the weakly electric fish Apteronotus leptorhynchus
Urethane and MS-222 are agents widely employed for general anesthesia, yet, besides inducing a state of unconsciousness, little is known about their...
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High-throughput volumetric map** of synaptic transmission
Volumetric imaging of synaptic transmission in vivo requires high spatial and high temporal resolution. Sha** the wavefront of two-photon...
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Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation
Amyloid beta (Aβ) is linked to the pathology of Alzheimer’s disease (AD). At physiological concentrations, Aβ was proposed to enhance neuroplasticity...
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Oxysterols in Central and Peripheral Synaptic Communication
Cholesterol is a key molecule for synaptic transmission, and both central and peripheral synapses are cholesterol rich. During intense neuronal...
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Morphology and receptive field organization of a temporal processing region in Apteronotus albifrons
The timing system of weakly electric fishes is vital for many behavioral processes, but the system has been relatively unexplored in Apteronotus...
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Ca2+ binding to synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals
Synapsin I (SynI) is a synaptic vesicle (SV)-associated phosphoprotein that modulates neurotransmission by controlling SV trafficking. The SynI...
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Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurological complications. The...
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The Role of cAMP in Topographic Organization of the Olfactory System
AbstractThe review article analyzes the literature data on the role of molecular olfactory receptors (ORs) and cAMP in the topographic organization...
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GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo
Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. Adult hippocampal neurogenesis is...
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Anti-Hebbian plasticity drives sequence learning in striatum
Spatio-temporal activity patterns have been observed in a variety of brain areas in spontaneous activity, prior to or during action, or in response...
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Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia. Despite enormous efforts around the world, there remains no effective cure for AD. This...
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Components of the GABAergic signaling in the peripheral cholinergic synapses of vertebrates: a review
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. Since the 1970s, many studies have...
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Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders
Post-synaptic specialization is critical to the neurotransmitter release and action potential conduction. The neuromuscular junctions (NMJs) are the...
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Biological Activities of the Alkaloids of the Calabar Bean
Ach (180) is the cationic neurotransmitter that in the central and peripheral nervous systems effects the transmission of action potentials across...
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Graph Theory-Based Approach in Brain Connectivity Modeling and Alzheimer’s Disease Detection
There is strong evidence that the pathological findings of Alzheimer’s disease (AD), consisting of accumulated amyloid plaques and neurofibrillary...
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The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation
The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet specific molecular pathways for neuronal ERK activation...
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Video-based pooled screening yields improved far-red genetically encoded voltage indicators
Video-based screening of pooled libraries is a powerful approach for directed evolution of biosensors because it enables selection along multiple...
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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle movement. Since...
