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Dose-dependent effects of gamma radiation sterilization on the collagen matrix of human cortical bone allograft and its influence on fatigue crack propagation resistance
Fatigue crack propagation resistance and high-cycle S–N fatigue life of cortical bone allograft tissue are both negatively impacted in a radiation...
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Calcium regulates primary nitrate response associated gene transcription in a time- and dose-dependent manner
Nitrate (NO 3 − ) is the primary source of nitrogen preferred by most arable crops, including wheat. The pioneering experiment on primary nitrate...
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Dose-Dependent Effects of Azospirilla Lectin on the Growth of Wheat Seedlings Under Salt Stress
AbstractThe dose-dependent effect of the A. brasilense Sp7 lectin on the roots of 4-day-old wheat seedlings ( Triticum aestivum L. cv. Saratovskaya...
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Sex-Specific and Dose-Dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats After Traumatic Brain Injury
Traumatic brain injury (TBI) ultimately leads to a reduction in the cerebral metabolic rate for oxygen due to ischemia. Previously, we showed that...
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Acaricidal action of ozone on larvae and engorged females of Rhipicephalus microplus: a dose-dependent relationship
The tick Rhipicephalus microplus is a vector of infectious agents that causes great economic loss in the productivity of cattle herds. Several...
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Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
Acetaminophen and ibuprofen are widely used over-the-counter medications to reduce fever, pain, and inflammation. Although both drugs are safe in...
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The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves...
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Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice
Transcriptome profiles are sensitive to space stressors and serve as valuable indicators of the biological effects during spaceflight. Herein, we...
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Zoledronic Acid Deteriorates Soft and Hard Tissue Healing of Murine Tooth Extraction Sockets in a Dose-Dependent Manner
The pathophysiology, histopathology, and immunopathology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) Stage 0 remain unclear. The aim...
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Dose-dependent Plant-promoting Effect of Macroalgae Stypopodium schimperi Extracts in Solanum lycopersicum and Detection of Phloroglucinol Composition
This study aimed to investigate using Stypopodium schimperi , brown alga extract, as a biofertilizer. Algae can be an essential bio-stimulant that...
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Time- and Dose-Dependent Toxicity Studies in 3D Cultures Using a Luminescent Lactate Dehydrogenase Assay
Three-dimensional (3D) in vitro systems closely resemble tissue microenvironments and provide predictive models for studying cytotoxic drug...
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Protection of Arsenic Induced Oxidative Stress in Reproductive Organs and Female Infertility by Pectic Polysaccharide of Momordica charantia: An In Vivo Study in dose Dependent Manner
Arsenic is a serious environmental pollutant and reprotoxic agent. Pectic Polysaccharide (CCPS) from Momordica charantia is an antioxidant used to...
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Dose-dependent therapeutic effects of topical 1,25 OH-vitamin D3 on corneal wound healing
Conflicting results have been reported regarding the effects of 1,25 OH-vitamin D 3 on corneal wound healing. Therefore, we undertook this study to...
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Dose-Dependent Oxidative Damage in Erythrocytes and Hepatic Tissue of Wistar Rats Concurrently Exposed with Arsenic and Quinalphos: a Subacute Study
Concurrent exposure to a multitude of environmental toxicants pose serious health hazard to humans and animals. The present investigation was...
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Determination of Dose-Dependent Toxic Effect of Coronatine, a Bacterial Phytotoxin, with the Help of Physiological, Cytogenetic, Biochemical, and Anatomical Parameters Using the Allium cepa Test Model
AbstractThe toxicity profile of coronatine (COR), a toxin produced by Pseudomonas bacteria using the Allium cepa test plant was determined with the...
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Genome-wide association analysis reveals that EDNRB2 causes a dose-dependent loss of pigmentation in ducks
BackgroundBirds have various plumage color patterns, and spot is a common phenotype. Herein, we conducted genome-wide association studies (GWAS) in a...
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Time and dose-dependent effect of preconditioning with sodium nitroprusside (SNP) and 3-morpholinosydnonimine (SIN-1) on post-thaw semen quality of Karan-Fries (KF) bulls
A novel strategy, focused on the induction of sub-lethal oxidative stress to optimize sperm cryosurvival, has been used before cryopreservation. The...
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Lipid headgroup and side chain architecture determine manganese-induced dose dependent membrane rigidification and liposome size increase
Metal ion-membrane interactions have gained appreciable attention over the years resulting in increasing investigations into the mode of action of...
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Comparative dose-dependent stress responses of endosulfan and its isomers (α & β) in non-target insect model, Drosophila melanogaster Meigen
In the present study, an attempt to evaluate the concentration-dependent responses of an organochlorine insecticide, endosulfan and its isomers (α...
