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Y-Chromosome Deletion Testing in Infertility
Y-chromosome harbours genes critical for gonadal development and the maintenance of spermatogenesis. Deletions in the AZF region of the Y-chromosome...
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Efficient and precise genomic deletion in rice using enhanced prime editing
Efficient and precise genomic deletion shows promise for investigating the function of proteins in plant research and enhancing agricultural traits....
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Neuronal Gtf2i deletion alters mitochondrial and autophagic properties
Gtf2i encodes the general transcription factor II-I (TFII-I), with peak expression during pre-natal and early post-natal brain development stages....
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A New Method for Gene Deletion to Investigate Cell Wall Biogenesis in Fusobacterium nucleatum
Controlled septal peptidoglycan hydrolysis is vital for bacterial cell division, preserving cellular integrity and facilitating proper daughter cell...
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A large deletion conferring pale green leaves of maize
BackgroundThe structural basis of chloroplast and the regulation of chloroplast biogenesis remain largely unknown in maize. Gene mutations in these...
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New candidate region for mirror hand movements: two patients with terminal 9p deletion and 20p duplication
The 9p deletion syndrome, which was defined in a detailed way in the previous studies, was characterized by various clinical features such as...
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CRISPR-Cas9-mediated deletion enhancer of MECOM play a tumor suppressor role in ovarian cancer
MDS1 and EVI1 complex locus (MECOM), a transcription factor encoding several variants, has been implicated in progression of ovarian cancer. The...
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Recombineering-Mediated Sinorhizobium meliloti Rm1021 Gene Deletion
Sinorhizobium meliloti Rm1021 ( S. meliloti Rm1021) is a Gram-negative, soil-dwelling α-proteobacterium which serves as a model microorganism for the...
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Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
We previously found that global deletion of the mitochondrial enzyme arginase 2 (A2) limits optic nerve crush (ONC)-induced neuronal death. Herein,...
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A chromosome 16 deletion conferring a high sucrose phenotype in soybean
Key messageSucrose in soybean seeds is desirable for many end-uses. Increased sucrose contents were discovered to associate with a chromosome 16...
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Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice
Myelodysplastic syndromes (MDS) are a heterogeneous group of pre-leukemic hematopoietic disorders characterized by cytopenia in peripheral blood due...
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Transcriptome Analysis of a Wine Yeast Strain with a Deletion of the CAR1 Arginase Gene
Abstract —Ethyl carbamate, a potential carcinogen, is formed in wine as a result of a chemical reaction between ethanol and urea during fermentation...
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Sensing chemical-induced DNA damage using CRISPR/Cas9-mediated gene-deletion yeast-reporter strains
AbstractMicroorganism-based genotoxicity assessments are vital for evaluating potential chemical-induced DNA damage. In this study, we developed both...
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Special clinical entity with 15q26 deletion: a novel case report
In the past, there were no easily distinct and recognizable features as a guide for precise clinical and genetic diagnosis of cases with chromosome...
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Deletion of gene OV132 attenuates Orf virus more effectively than gene OV112
AbstractOrf virus (ORFV), a Parapoxvirus in Poxviridae , infects sheep and goats resulting in contagious pustular dermatitis. ORFV is regarded as a...
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Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo
During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo...
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Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis
Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative...
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Deletion of 184–188 Nucleotides of Human Telomerase RNA Does Not Affect the Telomerase Functioning
AbstractTelomerase is a ribonucleoprotein complex, the main components of which are telomerase RNA and reverse transcriptase. Previously, it was...
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Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity
Insulin resistance is an early complication of diet-induced obesity (DIO)
1 , potentially leading to hyperglycaemia and hyperinsulinaemia, accompanied...
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Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy
Duchenne Muscular Dystrophy (DMD) is a progressive muscle wasting disorder caused by loss-of-function mutations in the dystrophin gene. Although the...
