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Application of In Silico Analysis to Determine Morphogenesis in Plant Tissue Culture
AbstractThe work proposed and tested a new approach to optimizing biotechnological processes, including the process of microclonal propagation. The...
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Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis
Integrated in vitro models of human organogenesis are needed to elucidate the multi-systemic events underlying development and disease. Here we...
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Reverse engineering morphogenesis through Bayesian optimization of physics-based models
Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is...
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Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis
Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue. E-cadherin–catenin complexes mediate Ca 2+ -dependent trans- homodime...
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3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially organized crypt–villus characteristics. This unique...
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Organotypic 3D Cell Culture of the Embryonic Lacrimal Gland
Ectodermal organ development, including lacrimal gland, is characterized by an interaction between an epithelium and a mesenchyme. Murine lacrimal...
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Computational Systems Biology of Morphogenesis
Extracting mechanistic knowledge from the spatial and temporal phenotypes of morphogenesis is a current challenge due to the complexity of biological...
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Adherens junctions as molecular regulators of emergent tissue mechanics
Tissue and organ development during embryogenesis relies on the collective and coordinated action of many cells. Recent studies have revealed that...
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A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis
Among morphological phenomena, cellular patterns in develo** sensory epithelia have gained attention in recent years. Although physical models for...
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Differentiation of Fibroblasts to Adipocytes in 3D for a Co-culture with Mammary Organoids and Immunohistological Analysis
Mammary epithelial ducts, the main functional compartment of the mammary gland, are embedded in an adipocyte-rich stroma, which is essential for...
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3D Cell Culture Techniques
To better understand human physiology and its development and pathological conditions, in vitro cell culture models are recognised as effective...
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An Introduction to Plant Cell, Tissue, and Organ Culture: Current Status and Perspectives
Plant cell, tissue, and organ cultures (PCTOC) have been used as experimental systems in basic research, allowing gene function demonstration through...
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Monitoring Effects of Membrane Traffic Via Changes in Cell Polarity and Morphogenesis in Three-Dimensional Human Pluripotent Stem Cell Cysts
Membrane traffic at the Golgi and endosomes plays many critical roles in the polarization and the morphogenesis of epithelial tissues. Studies into...
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Salivary Gland Development in Culture
Salivary glands are branching organs which develop by bud and cleft formation to create an organ with a large surface area. The epithelium and...
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3D Cell Culture: Techniques For and Beyond Organoid Applications
In the rapidly evolving landscape of cell biology and biomedical research, three-dimensional (3D) cell culture has contributed not only to the...
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Fibroblast-Epithelium Co-culture Methods Using Epithelial Organoids and Cell Line–Derived Spheroids
Fibroblasts are an integral cell type of mammary gland stroma, which plays crucial roles in development, homeostasis, and tumorigenesis of mammary...
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Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types
Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and collecting duct (CD) epithelia is essential to kidney...
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Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Morphogenesis and cell state transitions must be coordinated in time and space to produce a functional tissue. An excellent paradigm to understand...
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Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis
The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. Laboratory...
