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Crystal Structure Analysis of SH2 Domains in Complex with Phosphotyrosine Peptides
While the number of tertiary structures solved by cryoelectron microscopy has rapidly increased, X-ray crystallography is still a popular method to...
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Determination of the Crystal Structure of the Cell Wall-Anchored Proteins and Pilins
Surface proteins and pili (or pilus) anchored on the Gram-positive bacterial cell wall play a vital role in adhesion, colonization, biofilm...
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The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion
The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and movement of nuclear contents. It is formed of nuclear...
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Design, synthesis, and structure–activity relationship study of novel plinabulin derivatives as anti-tumor agents based on the co-crystal structure
Plinabulin, a 2, 5-diketopiperazine-type tubulin inhibitor derived from marine natural products, is currently undergoing Phase III clinical trials...
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Single-crystal structure determination of nanosized metal–organic frameworks by three-dimensional electron diffraction
Metal–organic frameworks (MOFs) have attracted considerable interest due to their well-defined pore architecture and structural tunability on...
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Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72
BackgroundThe first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many...
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The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition
Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune...
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Study of multifunctional anti-AD ligands: design, synthesis, X-ray crystal structure and biological evaluation of diosmetin derivatives
The development of anti-AD drugs has attracted much attention as the number of AD patients is increasing year by year. Five diosmetin derivatives ( 1–5 ...
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Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms
Streptococcus pyogenes harboring an FCT type 3 genomic region display pili composed of three types of pilins. In this study, the structure of the...
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Crystal structure of the phage-encoded N-acetyltransferase in complex with acetyl-CoA, revealing a novel dimeric arrangement
Bacteriophages employ diverse mechanisms to facilitate the proliferation of bacteriophages. The Salmonella -infecting phage SPN3US contains a putative...
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Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model
Ubiquitination is an important modification process in eukaryotic organisms, and ubiquitin ligase (E3) is the most diversified component of this...
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A facile preparation and crystal structure of romipeptide A
A double disulfide tethering depsipeptide dimer, romipeptide A ( 1 ) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was...
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Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation
Lamins are intermediate filaments that form a 3-D meshwork in the periphery of the nuclear envelope. The recent crystal structure of a long fragment...
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Crystal structure of metagenomic β-glycosidase MeBglD2 in complex with various saccharides
AbstractMetagenomic MeBglD2 is a glycoside hydrolase family 1 (GH1) β-glycosidase that has β-glucosidase, β-fucosidase, and β-galactosidase...
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Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain
Since unicellular parasites highly depend on NADPH as a source for reducing equivalents, the pentose phosphate pathway, especially the first and...
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Gradient characteristics of crystal, chemical structure, and nanoscale mechanical properties in the transcrystallinity of bamboo fiber anchored nano-TiO2/PP composites
Transcrystallinity (TC), a particular crystal structure located between natural fiber and matrix, provides a possibility to enhance the interfacial...
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Crystal structure of ChbG from Klebsiella pneumoniae reveals the molecular basis of diacetylchitobiose deacetylation
The chitobiose ( chb ) operon is involved in the synthesis of chitooligosaccharide and is comprised of a BCARFG gene cluster. ChbG encodes a...
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Microgravity environment grown crystal structure information based engineering of direct electron transfer type glucose dehydrogenase
The heterotrimeric flavin adenine dinucleotide dependent glucose dehydrogenase is a promising enzyme for direct electron transfer (DET)...
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The crystal structure of Cry78Aa from Bacillus thuringiensis provides insights into its insecticidal activity
Genetically modified plants with insecticidal proteins from Bacillus thuringiensis (Bt) have been successfully utilized to control various kinds of...
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X-ray Crystal Structure Analysis of VHH–Protein Antigen Complexes
VHHs are antigen-binding domains cloned from heavy-chain antibodies found in camelids. These proteins have generated considerable interest in a...