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Identifying critical transitions in complex diseases
Mortality and the burden of diseases worldwide continue to reach substantial numbers with societal development and urbanization. In the face of...
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Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions
BackgroundSpermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC...
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Decoding the complexities of transitions in football: a comprehensive narrative review
BackgroundTransitions in football are pivotal moments in the game, carrying significant tactical and strategic implications. Despite the lack of...
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From Cell States to Cell Fates: Control of Cell State Transitions
We examine the coordinated behavior of thousands of genes in cell fate transitions through genome expression as an integrated dynamical system using...
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Data-driven energy landscape reveals critical genes in cancer progression
The evolution of cancer is a complex process characterized by stable states and transitions among them. Studying the dynamic evolution of cancer and...
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Early Warning Signals for Rate-induced Critical Transitions in Salt Marsh Ecosystems
Intertidal ecosystems are important because of their function as coastal protection and ecological value. Sea level rise may lead to submergence of...
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Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in...
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Critical transitions and tip** points in EMT
BackgroundPhase transition and phase separation as well as their tip** points are penetrating phenomena in biology and are intrinsic properties of...
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Identifying critical transitions in seasonal shifts of zooplankton composition in a confined coastal salt marsh
Zooplankton assemblages in the confined coastal lagoons of La Pletera salt marshes (Baix Ter wetlands, Girona, Spain) are dominated by two species:...
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MIWE: detecting the critical states of complex biological systems by the mutual information weighted entropy
Complex biological systems often undergo sudden qualitative changes during their dynamic evolution. These critical transitions are typically...
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Transitions and its indicators in mutualistic meta-networks: effects of network topology, size of metacommunities and species dispersal
Gradual changes in the environment could cause dynamical ecological networks to suddenly shift from one state to an alternative state. When this...
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Continuous millisecond conformational cycle of a DEAH box helicase reveals control of domain motions by atomic-scale transitions
Helicases are motor enzymes found in every living organism and viruses, where they maintain the stability of the genome and control against false...
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Reconciling grain production and environmental costs during rural livelihood transitions: a simulation-based approach in southern China
Tension is building up between the need to provide food for eight billion humans and the necessity to safeguard their environment. In many parts of...
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Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Morphogenesis and cell state transitions must be coordinated in time and space to produce a functional tissue. An excellent paradigm to understand...
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Key research challenges to supporting farm transitions to agroecology in advanced economies. A review
In response to the sustainability issues that agriculture faces in advanced economies, agroecology has gained increasing relevance in scientific,...
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Change-point models for identifying behavioral transitions in wild animals
Animal behavior can be difficult, time-consuming, and costly to observe in the field directly. Innovative modeling methods, such as hidden Markov...
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Effects of noise correlation and imperfect data sampling on indicators of critical slowing down
Critical slowing down-based early warning signals (EWSs) are well-known indicators that precede an approaching collapse in complex systems. To date,...
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Sediment DNA Records the Critical Transition of Bacterial Communities in the Arid Lake
It is necessary to predict the critical transition of lake ecosystems due to their abrupt, non-linear effects on social-economic systems. Given the...
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Evolutionary transitions in diet influence the exceptional diversification of a lizard adaptive radiation
BackgroundDiet is a key component of a species ecological niche and plays critical roles in guiding the trajectories of evolutionary change. Previous...
