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Strengths and weaknesses of pneumococcal conjugate vaccines
Multivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the...
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Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines
Self-adjuvanting vaccines, covalent conjugates between antigens and adjuvants, are chemically well-defined compared with conventional vaccines...
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Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate
Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the...
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Heterologous Expression of Recombinant Proteins and Their Derivatives Used as Carriers for Conjugate Vaccines
AbstractCarrier proteins that provide an effective and long-term immune response to weak antigens has become a real breakthrough in the disease...
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A VEGFR targeting peptide-drug conjugate (PDC) suppresses tumor angiogenesis in a TACE model for hepatocellular carcinoma therapy
Transcatheter arterial chemoembolization (TACE) has become the preferred therapy for unresectable advanced hepatocellular carcinoma (HCC). However,...
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Hybrid Antimicrobial Coating Based on Conjugate of Hyaluronic Acid with LL-37 Peptide for PEO-Modified Titanium Implants
AbstractObjective: Synthesis of a novel conjugate of hyaluronic acid (HA) and the antimicrobial peptide LL-37 and evaluation of its antibacterial...
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Designing a novel drug–drug conjugate as a prodrug for breast cancer therapy: in silico insights
Breast cancer (BC) poses a significant global health threat, necessitating innovative therapeutic approaches. The ribosomal s6 kinase 2 (RSK2) has...
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Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma
BackgroundMelanoma is the most lethal skin cancer characterized by its high metastatic potential. In the past decade, targeted and immunotherapy have...
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Production and characterisation of modularly deuterated UBE2D1–Ub conjugate by small angle neutron and X-ray scattering
This structural study exploits the possibility to use modular protein deuteration to facilitate the study of ubiquitin signalling, transfer, and...
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Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer
Colorectal cancer (CRC) is the third most common cancer associated with a poor prognosis. Effective targeted therapy alone or in combination for...
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Preclinical development of the quadrivalent meningococcal (ACYW) tetanus toxoid conjugate vaccine, MenQuadfi®
Bacterial capsular polysaccharide vaccines are generally poorly immunogenic in infants and older adults. The immunogenicity of capsular...
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Synthesis and Characterization of Dipeptide–Drug Conjugate: The Use of Linker Coupling Reaction
Most of the effective anticancer drugs available in the market suffer from adverse effects due to their lack of target specificity. Therefore, so...
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Nanobody-peptide-conjugate (NPC) for passive immunotherapy against SARS-CoV-2 variants of concern (VoC): a prospective pan-coronavirus therapeutics
The COVID-19 crisis, incited by the zoonotic SARS-CoV-2 virus, has quickly escalated into a catastrophic public health issue and a grave threat to...
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Assessing the Potential of Vitamin Drug Conjugate for Its Activity against Infectious Disease
AbstractObjective: This study explores vitamin drug conjugates, linking drugs to targeting moieties (Niacin and Pantothenic acid), aiming to enhance...
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Copper-catalyzed C2-selective alkynylation of chromones via 1,4-conjugate addition
Copper-catalyzed selective alkynylation with N -propargyl carboxamides as nucleophiles has been successfully developed for the synthesis of...
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Serotype-specific quantification of residual free polysaccharide in multivalent pneumococcal conjugate vaccines
The Streptococcus pneumoniae bacteria has over 100 known serotypes that display a continuous change in prevalence by patients’ age and geographical...
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A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway
Human epidermal growth factor receptor 2 (HER2) is a protein that is overexpressed in some types of cancer, including breast and urothelial cancer....
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LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma
Despite clinical advances in diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death, and is...
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Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer
To explore highly selective targeting molecules of colorectal cancer (CRC) is a challenge. We previously identified a twelve-amino acid peptide...
