Search
Search Results
-
Phosphatidylserine Regulation of Coagulation Proteins Factor IXa and Factor VIIIa
Blood coagulation is an intricate process, and it requires precise control of the activities of pro- and anticoagulant factors and sensitive...
-
Unique properties of prothrombin in the bullhead shark Heterodontus japonicus: the first report of purification and characterization of a blood coagulation factor in Chondrichthyes
Prothrombin is a serine protease precursor of the blood coagulation system. In this study, the primary structure of prothrombin of a cartilaginous...
-
Diverse biological functions of vitamin K: from coagulation to ferroptosis
Vitamin K is essential for several physiological processes, such as blood coagulation, in which it serves as a cofactor for the conversion of...
-
Role of Platelet Activation in the Development and Metastasis of Solid Tumors
AbstractThe blood coagulation system is actively involved in the development of cancer. Many solid tumors express tissue factor (TF) that triggers a...
-
Cytosolic Calcium Distribution and Thrombin Receptor Activation
Since, receptor plays significant role in calcium signalling and to understand the mechanism of signalling in detail; an essential component is the...
-
Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective
The coagulation cascade represents a sophisticated and highly choreographed series of molecular events taking place in the blood with important...
-
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Coagulation factor IX (FIX) is a complex post-translationally modified human serum glycoprotein and high-value biopharmaceutical. The quality of...
-
Batroxin I: A Novel Bradykinin-Potentiating Peptide with Cytotoxic Activity Isolated from Bothrops atrox Snake Venom
Venom peptides are interesting molecular models for the development of biotechnological strategies applicable in generating therapeutic agents and/or...
-
Risk of Thrombosis and Mechanisms of Activation of Hemostasis in Divers after Diving
AbstractThe risks of decompression sickness and its complications in professional divers and amateur divers with various methods of diving in real...
-
Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology
BackgroundMultiple system atrophy (MSA) is a rare, progressive, neurodegenerative disorder presenting glia pathology. Still, disease etiology and...
-
Development of peptide-based biosensors for detecting cross-linking and deamidation activities of transglutaminases
Transglutaminases (TGs) are a protein family that catalyzes isopeptide bond formation between glutamine and lysine residues of various proteins....
-
Factor VIII and Factor V Membrane Bound Complexes
The formation of membrane-bound complexes between specific coagulation factors at different cell surfaces is required for effective blood clotting....
-
Role of LL-37 in thrombotic complications in patients with COVID-19
Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and a high-risk factor...
-
Reconstitution of (1→3)-β-D-glucans measurement system using recombinant Limulus polyphemus Factor G
AbstractHorseshoe crab Factor G is a heterodimeric serine protease zymogen that is activated by (1→3)-β-D-glucans (BDG) from fungal cell walls. This...
-
Regulation of Proinflammatory Activation of Cells RBL-2H3 by Activated Protein C and PAR1 Agonist Peptide
AbstractThis study was focused on the problem of regulation of the proinflammatory activity of mast cells through a specific class of...
-
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Platelet factors regulate wound healing and can signal from the blood to the brain
1 ,2 . However, whether platelet factors modulate cognition, a highly...
-
New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell–cell fusion
Coagulopathy and syncytial formation are relevant effects of the SARS-CoV-2 infection, but the underlying molecular mechanisms triggering these...
-
Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D
BackgroundEffective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and...
-
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn
IntroductionInflammation and nerve injury promote astrocyte activation, which regulates the development and resolution of pain, in the spinal dorsal...
-
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells
BackgroundSepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host...
