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Molecular regulation of hematopoietic stem cell quiescence
Hematopoietic stem cells (HSCs) are primarily dormant in a cell-cycle quiescence state to preserve their self-renewal capacity and long-term...
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Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation
In adult skeletal muscle, satellite cells are in a quiescent state, which is essential for the future activation of muscle homeostasis and...
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HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?
Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins are evolutionarily conserved integral membrane proteins. Mammalian LRIG1...
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Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that supports normal tissue turnover and can mount a...
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The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development
Maintaining stable and transient quiescence in differentiated and stem cells, respectively, requires repression of the cell cycle. The plant...
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Cell-intrinsic factors governing quiescence vis-à-vis activation of adult hematopoietic stem cells
Hematopoiesis is a highly complex process, regulated by both intrinsic and extrinsic factors. Often, these two regulatory arms work in tandem to...
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Indole-3-carboxaldehyde ameliorates ionizing radiation-induced hematopoietic injury by enhancing hematopoietic stem and progenitor cell quiescence
Indole-3-carboxaldehyde (I3A), one of tryptophan metabolites derived from gut microbiota, extends the lifespan of mice after high-dose ionizing...
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Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles
BackgroundCip1-interacting zinc finger protein 1 (CIZ1) forms RNA-dependent protein assemblies that stabilise epigenetic state, notable at the...
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An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence
Cellular quiescence is an important physiological state both in unicellular and multicellular eukaryotes. Quiescent cells are halted for...
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CD24 induced cellular quiescence-like state and chemoresistance in ovarian cancer cells via miR-130a/301a-dependent CDK19 downregulation
Cancer stem-like cell (CSC) is thought to be responsible for ovarian cancer recurrence. CD24 serves as a CSC marker for ovarian cancer and regulates...
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Measuring Endocytosis During Proliferative Cell Quiescence
Quiescence (also called “G0”) is the state in which cells have exited the cell cycle but are capable to reenter as required. Though poorly...
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The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse
BackgroundHair follicle stem cells (HFSC) play an essential role in the maintenance of hair homeostasis; during the hair cycle, HFSC remain quiescent...
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CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice
Hematopoietic stem cell (HSC) fate is tightly controlled by various regulators, whereas the underlying mechanism has not been fully uncovered due to...
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Chromatin Dynamics During Entry to Quiescence and Compromised Functionality in Cancer Cells
Quiescence is a vital cellular state where cells can reversibly exit the cell cycle and cease proliferation in unfavourable conditions. Cells can...
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mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation
BackgroundDuring skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning...
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Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism
Changes in maternal diet and metabolic defects in mothers can profoundly affect health and disease in their progeny. However, the biochemical...
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Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells
Patient-derived xenografted (PDX) models were generated through the transplantation of primary acute lymphoblastic leukemia (ALL) cells into...
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Stem Cell Exhaustion
In a lifetime, several insults occur in human tissues and therefore, the regenerative and repair processes play a crucial role maintaining tissue...