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The landscape of T cell antigens for cancer immunotherapy
The remarkable capacity of immunotherapies to induce durable regression in some patients with metastatic cancer relies heavily on T cell recognition...
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Outer membrane vesicles as a platform for the discovery of antibodies to bacterial pathogens
AbstractBacterial outer membrane vesicles (OMVs) are nanosized spheroidal particles shed by gram-negative bacteria that contain biomolecules derived...
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Atherosclerosis antigens as targets for immunotherapy
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction and stroke, underlying the first cause of...
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Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions
Vaccination is a valid strategy to prevent and control newly emerging and reemerging infectious diseases in humans and animals. However, synthetic...
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Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum
Malaria vaccine development is hampered by extensive antigenic variation and complex life stages of Plasmodium species. Vaccine development has...
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Other Non-α1,3Gal Antigens
Since understanding of the impact in xenoantigenic determinant Galα1,3Gal-R and anti-α1,3Gal Abs during xenoantigenic damages and injuries, other...
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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood
Matching donor and recipient blood groups based on red blood cell (RBC) surface ABO glycans and antibodies in plasma is crucial to avoid potentially...
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Protein–Protein Interaction: Bacterial Two Hybrid
The bacterial two-hybridBacterial two-hybrid (BACTH, for “Bacterial Adenylate Cyclase-based Two-Hybrid”) system is a simple and fast genetic approach...
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Isolation of Bacterial Extracellular Vesicles and Identification of Their Protein Cargo
Bacterial membrane vesicles (BMVs) are important effectors in the pathogenesis, virulence, and biofilm formation during different bacterial...
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Nanocarriers based on bacterial membrane materials for cancer vaccine delivery
Here we present a protocol for the construction and use of two types of nanocarrier based on bacterial membrane materials for cancer vaccine...
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Step-by-Step Bacterial Genome Comparison
Thanks to advancements in genome sequencing and bioinformatics, thousands of bacterial genome sequences are available in public databases. This...
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Sifting through the core-genome to identify putative cross-protective antigens against Riemerella anatipestifer
AbstractInfectious serositis of ducks, caused by Riemerella anatipestifer , is one of the main infectious diseases that harm commercial ducks....
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Bacterial Biofilm for Oral Vaccination in Aquaculture
Conventional bacterial free cell oral vaccines provide poor, inconsistent immune response and protection due to antigen destruction in stomach. A...
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Measurement of Antibody Binding Affinity on Bacterial Surfaces Using Flow Cytometry
Antibody binding to bacterial surfaces plays a crucial role in immunity, and a key characteristic of this protein–protein interaction is the binding...
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Enterohemorrhagic Escherichia coli O157:H7 antigens produced in transgenic lettuce effective as an oral vaccine in mice
Key messageTransgene with recombination sites to address biosafety concerns engineered into lettuce to produce EspB and γ -intimin C280 for oral...
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Bacterial capsules: Occurrence, mechanism, and function
In environments characterized by extended multi-stress conditions, pathogens develop a variety of immune escape mechanisms to enhance their ability...
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Rapid Surface Shaving for Proteomic Identification of Novel Surface Antigens for Vaccine Development
The bacterial cell surface (surfaceome) is the first site encountered by immune cells and is thus an important site for immune recognition. As such,...
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Purification of Prospective Vaccine Antigens from Gram-Positive Pathogens by Immunoprecipitation
Immunoprecipitation is an affinity purification technique that exploits the highly specific interactions formed between antibodies and their cognate...
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Identification of New Antibodies Targeting Tumor Cell Surface Antigens by Phage Display
The majority of therapeutic antibodies, bispecific antibodies, and chimeric antigen receptor (CAR) T cells in cancer therapy are based on an antibody...
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Structural properties of immune complexes formed by viral antigens and specific antibodies shape the inflammatory response of macrophages
Data on the course of viral infections revealed severe inflammation as a consequence of antiviral immune response. Despite extensive research, there...
