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mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth
BackgroundThe establishment and maintenance of functional neural connections relies on appropriate distribution and localization of mitochondria in...
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Real-time imaging of axonal membrane protein life cycles
The construction of neuronal membranes is a dynamic process involving the biogenesis, vesicular packaging, transport, insertion and recycling of...
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Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
BackgroundActivated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone...
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Studying the Role of P2X7 Receptor in Axonal Growth Using In Utero Electroporation Technique
The nervous system is formed by a complex network of neuronal connections. During development, neurons elongate their axons through highly...
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Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 G93A...
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Regulation of axonal regeneration after mammalian spinal cord injury
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern neuroscience, stated that neurons of the adult central nervous...
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Fibroblast growth factor signaling in axons: from development to disease
The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established...
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DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release
Among the five members of the dual-specificity tyrosine-phosphorylation-regulated kinase (DYRK) family, the cellular functions of DYRK3 have not been...
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Microfluidic devices as model platforms of CNS injury-ischemia to study axonal regeneration by regulating mitochondrial transport and bioenergetic metabolism
Central nervous system (CNS) neurons typically fail to regenerate their axons after injury leading to neurological impairment. Axonal regeneration is...
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JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton
Lysosome axonal transport is important for the clearance of cargoes sequestered by the endocytic and autophagic pathways. Building on observations...
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Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons
Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due...
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Axonal degeneration induces distinct patterns of phosphatidylserine and phosphatidylethanolamine externalization
Axonal degeneration is a common feature of multiple neurodegenerative diseases, yet the mechanisms underlying its various manifestations are...
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Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling
Astrocytes are important components of the innate immune response in the central nervous system (CNS), involving in the inflammatory and neurotoxic...
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CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive optic nerve degeneration and retinal ganglion...
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In Vivo Live Imaging of Axonal Transport in Develo** Zebrafish Axons
Axonal transport is crucial for neuronal homeostasis, survival, and development. Indeed, axonal transport needs to be precisely regulated for...
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Analyzing the Impact of Gene Mutations on Axonal Transport in Caenorhabditis Elegans
The development and functions of neurons are supported by axonal transport. Axonal transport is a complex process whose regulation involves multiple...
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Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
BackgroundSpinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell...
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Use of Microfluidics Chambers to Image Axonal transport in Adult Sensory Neurons
Transport of cargoes along axons is crucial for ensuring effective neuronal function and survival. Lysosomes, which are membrane-bound organelles...
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High-Resolution Live Imaging of Axonal RNP Granules in Drosophila Pupal Brain Explants
Dynamic and local adjustments of the axonal proteome are observed in response to extracellular cues and achieved via translation of axonally...
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Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the...
