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Environmental stress mediates groundwater microbial community assembly
Community assembly describes how different ecological processes shape microbial community composition and structure. How environmental factors impact...
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Comparison of assembly platforms for the assembly of the nuclear genome of Trichoderma harzianum strain PAR3
BackgroundTrichoderma is a diverse genus of fungi that includes several species that possess biotechnological and agricultural applications,...
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A roadmap for ribosome assembly in human mitochondria
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation...
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Uncovering the photosystem I assembly pathway in land plants
Photosystem I (PSI) is one of two large pigment–protein complexes responsible for converting solar energy into chemical energy in all oxygenic...
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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP)...
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Mechanism of autocatalytic activation during proteasome assembly
Many large molecular machines are too elaborate to assemble spontaneously and are built through ordered pathways orchestrated by dedicated...
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Defining Assembly Pathways by Fluorescence Microscopy
Bacterial secretion systems are among the largest protein complexes in prokaryotes and display remarkably complex architectures. Their assembly often...
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High-quality metagenome assembly from long accurate reads with metaMDBG
We introduce metaMDBG, a metagenomics assembler for PacBio HiFi reads. MetaMDBG combines a de Bruijn graph assembly in a minimizer space with an...
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Constructing telomere-to-telomere diploid genome by polishing haploid nanopore-based assembly
Draft genomes generated from Oxford Nanopore Technologies (ONT) long reads are known to have a higher error rate. Although existing genome polishers...
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A Comprehensive Pan-Cancer Analysis of Cytochrome C Oxidase Assembly Factor 1 (COA1) Reveals Instrumental Role of Mitochondrial Protein Assembly in Cancer that Modulates Disease Progression and Prognostic Outcome
Cytochrome c oxidase assembly factor 1 (COA1), a mitochondrial respiratory chain complex assembly factor protein of inner mitochondrial membrane...
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Scalable telomere-to-telomere assembly for diploid and polyploid genomes with double graph
Despite advances in long-read sequencing technologies, constructing a near telomere-to-telomere assembly is still computationally demanding. Here we...
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Haplotype-resolved assembly of a pig genome using single-sperm sequencing
Single gamete cell sequencing together with long-read sequencing can reliably produce chromosome-level phased genomes. In this study, we employed...
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Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division. Following more than a century of study, many components and...
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ONT read assembly of the black rhino genome
ObjectivesThe black rhinoceros ( Diceros bicornis ) is an endangered mammal for which a captive breeding program is part of the conservation effort....
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A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells
The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for innovative therapies with high genetic barriers to...
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Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity
On-demand biomanufacturing has the potential to improve healthcare and self-sufficiency during space missions. Cell-free transcription and...
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Sequencing and Assembly of Polyploid Genomes
Polyploidy has been observed throughout major eukaryotic clades and has played a vital role in the evolution of angiosperms. Recent polyploidizations...
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Environmental filtering mediates desert ant community assembly at two spatial scales
Understanding the mechanisms that maintain species coexistence and determine patterns of community assembly are fundamental goals of ecology....
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Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
Isolated complex I (CI) deficiencies are a major cause of primary mitochondrial disease. A substantial proportion of CI deficiencies are believed to...
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NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads
Long-read sequencing data, particularly those derived from the Oxford Nanopore sequencing platform, tend to exhibit high error rates. Here, we...
