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Prediction of antischistosomal small molecules using machine learning in the era of big data
Schistosomiasis is a neglected tropical disease caused by helminths of the Schistosoma genus. Despite its high morbidity and socio-economic burden,...
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Target-based discovery of a broad-spectrum flukicide
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases—for example, the parasitic blood...
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Multivariate chemogenomic screening prioritizes new macrofilaricidal leads
Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the...
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Biosynthesis of Novel Naphthoquinone Derivatives in the Commonly-used Chassis Cells Saccharomyces cerevisiae and Escherichia coli
Naphthoquinones harboring 1,4-naphthoquinone pharmacophore are considered as privileged structures in medicinal chemistry. In pharmaceutical industry...
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Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni
Drug discovery for schistosomiasis is still limited to a handful of academic laboratories worldwide, with only a few novel antischistosomal lead...
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Effect of Processing on the Composition and Quality of Nigella sativa Essential Oil
Nigella sativa L. is an annual herb of the Ranunculaceae family. The seeds called black cumin seed which contains 34–39% oil. Its oil has many...
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Unearthing the fungal endophyte Aspergillus terreus for chemodiversity and medicinal prospects: a comprehensive review
Aspergillus terreus microorganism represents a promising prospective source for drug discovery since it is rich in diverse kinds of bioactive...
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The Role of Meta-topolin in Plant Morphogenesis In Vitro
Over 80% of world population relies on plant-based traditional medicine for health care. The genetic diversity of medicinal plants is declining due...
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Some Representative Medicinal Halophytes in Asia
Aerva javanica
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Usage of plant natural products for prevention and control of white feces syndrome (WFS) in Pacific whiteleg shrimp Litopenaeus vannamei farming in India
White feces syndrome (WFS) causes severe economic damages in Litopenaeus vannamei culture by the microsporidian parasite, Enterocytozoon hepatopenaei ...
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Medicinal Plants as a Source of Alkaloids
Plants are an important source of biomolecules widely used in medical treatments, and among such products, the alkaloids are a very interesting and...
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Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)
Echinoderms are a source of a broad range of secondary metabolites with a large variety of bioactive properties. Although pigment and lipid...
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A novel protocol for catalyst-free synthesis of fused six-member rings to triazole and pyrazole
AbstractHerein, an effectual, quick and novel method is described for the synthesis of new triazolo[1,5- a ]pyrimidine, triazolo[5,1- b ][1,3] thiazine...
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Factors Influencing the Production and Chemical Composition of Essential Oils in Aromatic Plants from Brazil
Medicinal and aromatic plants are plants rich in specialized metabolites, mainly the essential oils, which have several functions in plant species...
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The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased...
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Schistosoma Mansoni: Antiparasitic Effects of Orally Administered Nigella Sativa Oil and/or Chroococcus Turgidus Extract
Schistosoma mansoni is one of the parasites causing schistosomiasis, a disease which threatens millions of people all over the world. Traditional...
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Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes
Artemisinin, isolated from an annual herbaceous plant Artemisia annua L., is an effective antimalarial compound. However, artemisinin is accumulated...
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Liposomal systems as carriers for bioactive compounds
Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a...
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Eurycoma longifolia
Tongkat Ali sampling