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Enhanced antiproliferative activity of phycoerythrin through microencapsulation
Phycoerythrin, a phycobiliprotein recognized for its brilliant crimson hue and essential role in light harvesting during photosynthesis, was...
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The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells
(1R,2R-diaminocyclohexane)(dihydropyrophosphato) platinum(II), also abbreviated as RRD2, belongs to a class of potent antitumor platinum cytostatics...
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Synthesis and In vitro Antiproliferative Activity of 5-Halogen-6-nitrobenzo[c][1,2,5]selenadiazoles on A549 Cells
AbstractSelenadiazoles are of a broad spectrum of promising anticancer agents. However, excessive synthetic steps, larger molecular size and erratic...
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Antiproliferative, anti-inflammatory, and antioxidant activity of aqueous extracts from Origanum compactum benth aerial part
Origanum compactum Benth (Lamiaceae), is an endemic plant of northern Morocco. rich in phenolic compounds that is commonly used in traditional...
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In Vitro Cytotoxic Activity and In Vivo Antiproliferative Activity of Ethyl Acetate Fraction of Bunium bulbocastanum Seed Against Prostatic Neoplasia
Several in vitro investigations of the therapeutic characteristics of B. bulbocastanum have shown that it has cytotoxic, antifungal, and...
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Antioxidant, Antimicrobial, and Antiproliferative Activities of Some Edible Wild Mushrooms
AbstractEdible mushrooms are dietary products that are widely consumed in many societies. It is known that mushrooms, which stand out with their...
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Synthesis, antiproliferative activity, and molecular modeling of novel 4-methylcoumarin derivatives and/or nitric oxide donor hybrids
AbstractTwo new 4-methylcoumarin derivatives ( 3a–f and 4a–f ) were designed, synthesized, and evaluated for their cytotoxic activity. Different...
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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization
New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j ...
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Aspergillus Niger thermostable Cytosine deaminase-dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity
Cytosine deaminase (CDA) is a prodrug mediating enzyme converting 5-flurocytosine into 5-flurouracil with profound broad-range anticancer activity...
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Citrus Essential Oils: A Rational View on its Chemical Profiles, Mode of Action of Anticancer Effects/Antiproliferative Activity on Various Human Cancer Cell Lines
Cancer is a complex genetic disorder due to uncontrolled growth of abnormal cells in the body, causes damage to the immune system, and may lead to...
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Synthesis of bis-thiohydantoin derivatives as an antiproliferative agents targeting EGFR inhibitory pathway
( R )/( S )-the two enantiomers of...
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Bioprocessing of Epothilone B from Aspergillus fumigatus under solid state fermentation: Antiproliferative activity, tubulin polymerization and cell cycle analysis
Epothilone derivatives have been recognized as one of the most powerful anticancer drugs towards solid tumors, for their unique affinity to bind with...
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Identification of anthocyanins in a purple yam (Dioscorea alata) accession and their in vitro antiproliferative activity
The chemical structure and in vitro anti-proliferative activity of anthocyanins isolated from the tubers of a purple yam ( Dioscorea alata ) accession...
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Genome mining reveals secondary metabolites of Antarctic bacterium Streptomyces albidoflavus related to antimicrobial and antiproliferative activities
The urgent need for new antimicrobials arises from antimicrobial resistance. Actinobacteria, especially Streptomyces genus, are responsible for...
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Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent antiproliferative agents
To discover new Werner (WRN) helicase inhibitors, a series of N -aryl-2-trifluoromethyl-quinazoline-4-amine derivatives were designed and synthesized...
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Design, Synthesis, Molecular Docking Anticancer, Antiproliferative and Antioxidant Studies of Novel Chalcones Derivatives
AbstractA series of chalcones were synthesized and characterized by different spectroscopic techniques. The antioxidant properties of the compounds...
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Antimicrobial, antiproliferative activities and molecular docking of metabolites from Alternaria alternata
Endophytic fungi allied to plants have sparked substantial promise in discovering new bioactive compounds. In this study, propagation of the...
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An efficient one-pot synthesis and docking studies of bioactive new antiproliferative dispiro[oxindole/acenaphthylenone‒benzofuranone] pyrrolidine scaffolds
A new and efficient method has been developed to synthesize dispiro[oxindole/acenaphthylenone-benzofuranone]pyrrolidine compounds. This is done by...
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Chemical Composition and In Vitro Antimicrobial, Antioxidant, and Antiproliferative Studies of the Lamium galeobdolon L. (L.) Essential Oil
AbstractThe current study aimed to evaluate the chemical composition and bioactive properties of Lamium galeobdolon (L.) L. After obtaining an...
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Design, spectroscopic characterizations, and biological investigation of oxospiro[chromine-4,3-indolene]-based compounds as promising antiproliferative EGFR inhibitors and antimicrobial agents
Utilizing microwave heating and an aqueous saturated solution of K 2 CO 3 as a catalyst, a rapidone-pot synthesis of oxospiro[chromene-4.3-indoline]...
