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Identification and characterization of a novel decalin derivative with anti-Candida activity from Streptomyces chrestomyceticus strain ADP4
A novel decalin derivative, trans-1-oxo-2,4-diacetylaminodecalin (1) with anti- Candida activity, had been isolated from Streptomyces chrestomyceticus ...
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Immune boosting functional components of natural foods and its health benefits
Naturally available foods contain nutrients like vitamins (A, C, E, and D), zinc, calcium, magnesium, folate iron, omega fatty acids, selenium, and...
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Asking the right questions for mutagenicity prediction from BioMedical text
Assessing the mutagenicity of chemicals is an essential task in the drug development process. Usually, databases and other structured sources for...
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Cellular toxicity and DNA damage induced by Newbouldia laevis used for male infertility treatment in prokaryotic and eukaryotic models
Leaves of Newbouldia laevis have been extensively used in solving problems associated with infertility and childbirth in many African countries. Yet,...
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Antibacterial and antibiofilm activity of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H pyrazoles and thiazoles in multidrug-resistant pathogens
To find novel antibiotic drugs, six 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H derivatives named 1b , 1d (pyrazoles), 2a , 2b , 2c, and 2d (thiazoles)...
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Recent advances in flavonoid compounds for the treatment of prostate cancer
Prostate cancer is a malignant epithelial tumor of the prostate gland and is the most common malignant tumor of the male genitourinary system....
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Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase
Alcoholic liver injury resulting from excessive alcohol consumption is a significant social concern. Alcohol dehydrogenase (ADH) plays a critical...
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Alterations in the gut microbiota and their metabolites in human intestinal epithelial cells of patients with colorectal cancer
BackgroundThe gut microbiota has become one of the main risk factors for the formation and development of colorectal cancer (CRC). CRC...
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Essential Oil Derived from Underutilized Plants Cymbopogon khasianus Poses Diverse Biological Activities against “Aspergillosis” and “Mucormycosis”
AbstractPalmrosa essential oil (PEO) from Cymbopogon khasianus , is used as complementary and traditional medicine worldwide. The present study aimed...
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Extraction and Quantification of Cylindrospermopsins from Aquatic Samples by ELISA
Most of the world’s population relies on surface freshwaters as its primary source for drinking water. The drinking water industry is constantly...
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Pesticides, cosmetics, drugs: identical and opposite influences of various molecular features as measures of endpoints similarity and dissimilarity
AbstractThe similarity is an important category in natural sciences. A measure of similarity for a group of various biochemical endpoints is...
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Deciphering the multi-functional role of Indian propolis for the management of Alzheimer’s disease by integrating LC–MS/MS, network pharmacology, molecular docking, and in-vitro studies
The conventional one-drug-one-disease theory has lost its sheen in multigenic diseases such as Alzheimer’s disease (AD). Propolis, a honeybee-derived...
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Synthesis and toxicological study of chitosan–pirul (Schinus molle L.) essential oil nanoparticles on Aspergillus flavus
In recent years, the study of essential oils as antifungal alternatives and their encapsulation to increase their properties for greater effects has...
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Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model
A new series of tetrahydroacridine derivatives with the fluorobenzoyl moiety was synthesized and evaluated for cytotoxic activity against lung cancer...
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Molecular Mechanism of Cynodon dactylon Phytosterols Targeting MAPK3 and PARP1 to Combat Epithelial Ovarian Cancer: A Multifaceted Computational Approach
Epithelial Ovarian Cancer (EOC) presents a global health concern, necessitating the development of innovative therapeutic strategies to combat its...
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Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M
AbstractEpidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers. In...
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Effects of Limonium effusum Ethanol Extracts on Cell Proliferation and Mutagenicity
Abstract — Limonium plants have commonly used as antibacterial, styptical, anti-swelling agent, digestive system regulator, anticarcinogenic, and...
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An investigation of the antioxidant potential and bioaccumulated minerals in Tuber borchii and Tuber maculatum mycelia obtained by submerged fermentation
Submerged fermentation of Tuber borchii and T. maculatum was performed to produce mycelia towards evaluating their bioactive potential and probable...
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Inhibition of Monkeypox Virus DNA Polymerase Using Moringa oleifera Phytochemicals: Computational Studies of Drug-Likeness, Molecular Docking, Molecular Dynamics Simulation and Density Functional Theory
The emergence of zoonotic monkeypox (MPX) disease, caused by the double-stranded DNA monkeypox virus (MPXV), has become a global threat. Due to...
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Identification of potential flavonoid compounds as antibacterial therapeutics against Klebsiella pneumoniae infection using structure-based virtual screening and molecular dynamics simulation
Klebsiella pneumoniae , which is among the top three pathogens on WHO's priority list, is one of the gram-negative bacteria that doctors and...
