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Advances in the allostery of angiotensin II type 1 receptor
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric...
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Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3
The sweet taste receptor plays an essential role as an energy sensor by detecting carbohydrates. However, the dynamic mechanisms of receptor...
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Allostery and protein plasticity: the keystones for bacterial signaling and regulation
Bacteria sense intracellular and environmental signals using an array of proteins as antennas. The information is transmitted from such sensory...
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Allostery Methods and Protocols
This volume explores the basic issues of “allostery” and “network” that are fundamental to studying this field. Chapters in this book look at how the...
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Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport
The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that governs motor function and intracellular localization (for...
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Cooperativity and Allostery in RNA Systems
Allostery is among the most basic biological principles employed by biological macromolecules to achieve a biologically active state in response to...
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Disclosing Allostery Through Protein Contact Networks
Proteins are located in the twilight zone between chemistry and biology, where a peculiar kind of complexity starts. Proteins are the smallest...
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Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature
Multimeric protein assemblies are abundant in nature. Streptavidin is an attractive protein that provides a paradigm system to investigate the intra-...
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Talin and kindlin use integrin tail allostery and direct binding to activate integrins
Integrin affinity regulation, also termed integrin activation, is essential for metazoan life. Although talin and kindlin binding to the β-integrin...
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Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells
The incorporation of light-responsive domains into engineered proteins has enabled control of protein localization, interactions and function with...
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Revealing Allostery in PTPN11 SH2 Domains from MD Simulations
Src-homology 2 (SH2) domains are protein interaction domains that bind to specific peptide motifs containing phosphotyrosine. SHP2, a tyrosine...
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Allostery: The Rebound of Proteins
The discovery of hemoglobin allosteric properties is briefly summarized and contextualized in the frame of the main biochemical revelations that...
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Network Re-Wiring During Allostery and Protein-Protein Interactions: A Graph Spectral Approach
The process of allostery is often guided by subtle changes in the non-covalent interactions between residues of a protein. These changes may be...
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Current Trends in GPCR Allostery
GPCRs remain the most important drug target comprising ~ 34% of the Food and Drug Administration (FDA)-approved drugs. In modern pharmacology of...
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Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch
Riboswitches normally regulate gene expression through structural changes in response to the specific binding of cellular metabolites or metal ions....
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Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Simulations
The p53 tumor suppressor is a multifaceted context-dependent protein, which is involved in multiple cellular pathways, with the ability to either...
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Hemoglobin: Structure, Function and Allostery
This chapter reviews how allosteric (heterotrophic) effectors andAllostery natural mutations impact hemoglobinHemoglobin (Hb) primary physiological...
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Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes
Differential scanning fluorimetry (DSF) is a technique that reports protein thermal stability via the selective recognition of unfolded states by...
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NMR Methods to Study the Dynamics of SH2 Domain–Phosphopeptide Complexes
Nuclear magnetic resonance (NMR) spectroscopy is the method of choice for studying the dynamics of biological macromolecules in solution. By...
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Probing Allosteric Mechanism with Long-Range Rigidity Transmission Across Protein Networks
Allosteric transmission refers to regulation of protein function at a distance. “Allostery” involves regulation and/or signal transduction induced by...