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An unexpected role of EasDaf: catalyzing the conversion of chanoclavine aldehyde to chanoclavine acid
AbstractErgot alkaloids (EAs) are a diverse group of indole alkaloids known for their complex structures, significant pharmacological effects, and...
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Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation
BackgroundThe development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting...
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A novel alkane monooxygenase evolved from a broken piece of ribonucleotide reductase in Geobacillus kaustophilus HTA426 isolated from Mariana Trench
We have accidentally found that a thermophilic Geobacillus kaustophilus HTA426 is capable of degrading alkanes although it has no alkane oxygenating...
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The revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens
BackgroundPerilla frutescens is widely used as both a medicine and a food worldwide. Its volatile oils are its active ingredients, and, based on the...
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Identification and functional characterization of a novel aldo–keto reductase from Aloe vera
Main conclusionThe present investigation profoundly asserted the catalytic potential of plant-based aldo-ketoreductase, postulating its role in...
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Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity
Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently...
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Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
HMG-CoA reductase (HMGR), a rate-limiting enzyme of the mevalonate pathway in Gram-positive pathogenic bacteria, is an attractive target for...
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Engineering of an ene-reductase for producing the key intermediate of antiepileptic drug Brivaracetam
Abstract( R )-4-Propyldihydrofuran-2(3H)-one ( R -PDFO) is the key chiral intermediate for the antiepileptic drug Brivaracetam. Lacking a simple and...
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Identification of a cinnamoyl-CoA reductase from Cinnamomum cassia involved in trans-cinnamaldehyde biosynthesis
Main conclusionThe identification of a functional cinnamoyl-CoA reductase enzyme from Cinnamomum cassia involved in trans- cinnamaldehyde...
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Functional characterization of a Colchicum autumnale L. double-bond reductase (CaDBR1) in colchicine biosynthesis
Main conclusionAn alkenal double-bond reductase enzyme ( Ca DBR1) was cloned from Colchicum autumnale L. The encoded enzyme catalysed 4-coumaraldehyde...
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Artificial microRNA mediated silencing of cyclase and aldo–keto reductase genes reveal their involvement in the plumbagin biosynthetic pathway
Plumbagin and other naphthoquinone derivatives from the Plumbago zeylanica L. (Plumbaginaceae) are known for their anticancer and other medicinal...
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New insights into two yeast BDHs from the PDH subfamily as aldehyde reductases in context of detoxification of lignocellulosic aldehyde inhibitors
At least 24 aldehyde reductases from Saccharomyces cerevisiae have been characterized and most function in in situ detoxification of lignocellulosic...
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Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors
In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from glucose. In order to detoxify some dangerous aldehydes, AR is...
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Aldehyde dehydrogenase superfamily in sorghum: genome-wide identification, evolution, and transcript profiling during development stages and stress conditions
BackgroundAldehyde dehydrogenases (ALDHs) are a family of NAD(P) + dependent enzymes that detoxify aldehydes by promoting their oxidation to...
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In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae
AbstractAldehydes are ubiquitous electrophilic compounds that ferment microorganisms including Saccharomyces cerevisiae encounter during the...
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Phylogenetic and functional diversity of aldehyde-alcohol dehydrogenases in microalgae
Key messageThe study shows the biochemical and enzymatic divergence between the two aldehyde-alcohol dehydrogenases of the alga Polytomella sp.,...
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Fatty acyl-CoA reductase influences wax biosynthesis in the cotton mealybug, Phenacoccus solenopsis Tinsley
Mealybugs are highly aggressive to a diversity of plants. The waxy layer covering the outermost part of the integument is an important protective...
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Distribution and functional analysis of the two types of 8-vinyl reductase involved in chlorophyll biosynthesis in marine cyanobacteria
In the chlorophyll biosynthesis pathway, the 8-vinyl group of the chlorophyll precursor is reduced to an ethyl group by 8-vinyl reductase. Two...
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Major aldehyde dehydrogenase AldFGH of Gluconacetobacter diazotrophicus is independent of pyrroloquinoline quinone but dependent on molybdopterin for acetic acid fermentation
AbstractAcetic acid fermentation involves the oxidation of ethanol to acetic acid via acetaldehyde as the intermediate and is catalyzed by the...
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Current Concepts of the Mechanisms of Nitric Oxide Formation in Plants
AbstractNitric oxide (NO) is a universal signaling molecule that functions in all living organisms. It is involved in the regulation of plant growth...
