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Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
BackgroundBoth glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ) play a critical role in adipocyte differentiation....
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Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation
Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy...
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Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis
BackgroundPrevious studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate...
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Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation
The role of bone morphogenetic proteins (BMPs) in regulating adipose has recently become a field of interest. However, the underlying mechanism of...
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H19X-encoded microRNAs induced by IL-4 in adipocyte precursors regulate proliferation to facilitate differentiation
Adipose tissue, an organ critical for systemic energy homeostasis, is influenced by type 2 immunity in its development and function. The type 2...
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Effects of Thymoquinone on Adipocyte Differentiation in Human Adipose-Derived Stem Cells
Inhibition of adipocyte differentiation would be a key strategy to control obesity. Human adipose tissue-derived stem cells (ADSCs) are a promising...
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Atomic force microscopy characterization of white and beige adipocyte differentiation
Adipose tissue plays an essential role in systemic metabolism with white adipose tissue (WAT) making up most of the tissue and being involved in the...
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Discovery, characterization, and adipocyte differentiation regulation in perirenal adipose tissue of large yellow croaker (Larimichthys crocea)
Adipose tissue is an essential tissue for lipid deposition in fish and is associated with excess lipid accumulation in aquaculture. However, the...
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Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway
BackgroundGut microbiota provide numerous types of metabolites that humans cannot produce and have a huge influence on the host metabolism....
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Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet
Obesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia...
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Assessing the Anti-Obesity Potential of Lactococcus lactis subsp. lactis CAB701: Modulation of Adipocyte Differentiation and Lipid Metabolism in In Vitro and In Vivo Models
In this study, the potential anti-obesity effects of Lactococcus lactis subsp. lactis CAB701, a probiotic strain isolated from cabbage, were...
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Oleoylethanolamide protects mesenchymal stem/stromal cells (MSCs) from oxidative stress and reduces adipogenic related genes expression in adipose-derived MSCs undergoing adipocyte differentiation
BackgroundHuman mesenchymal stem/stromal cells (hMSCs) are known for their pronounced therapeutic potential; however, they are still applied in...
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WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
BackgroundMetabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we...
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Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview
The adipose organ comprises two main fat depots termed white and brown adipose tissues. Adipogenesis is a process leading to newly differentiated...
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PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
PAQR4 is an orphan receptor in the PAQR family with an unknown function in metabolism. Here, we identify a critical role of PAQR4 in maintaining...
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Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation
BackgroundRecent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to...
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Adipocyte lipolysis protects mice against Trypanosoma brucei infection
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and inducing weight loss. Here we investigated the molecular mechanisms...
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A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
Obesity is endemic to many developed countries. Overweight or obesity is associated with an increased risk of develo** cancer. Dysfunctional...
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Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and...
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Molecular and Cellular Mechanisms Governing Adipogenic Differentiation
AbstractAdipose tissue is a special type of connective tissue that comprises stromal-vascular cells, committed preadipocytes, and mature adipocytes....
