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Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of...
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The Impact of Replacing Amino Acid Residues Ser-911 and Thr-912 in the Yeast Saccharomyces cerevisiae Plasma Membrane H+-ATPase on Its Activity and Polyphosphate Distribution
AbstractThe vital enzyme of yeast metabolism, the H + -ATPase of the plasma membrane (PMA1), is phosphorylated during folding and functioning. The...
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The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane
AbstractIonic liquids (ILs) are organic salts with a low melting point. This is due to the fact that their alkyl side chains, which are covalently...
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Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC...
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Plasma membrane-localized hexose transporter OsSWEET1b, affects sugar metabolism and leaf senescence
Key messageOsSWEET1b is a hexose transporter protein , which localized in cell membranes and interacting with itself to form homodimer and knockout of...
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Quantitative Measurements of Membrane Lipid Order in Yeast and Fungi
Membrane lateral heterogeneity, historically referred to as the lipid raft hypothesis, has been extensively investigated through physiochemical...
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Regulating membrane curvature
Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle...
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Mitochondria, metabolism, and aging in yeast
Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation....
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12 Baker’s Yeast: a rising foundation for eukaryotic sphingolipid-mediated cell signaling
Saccharomyces cerevisiae has been an invaluable tool for the dissection of sphingolipid metabolic pathways and cloning of enzymes involved in...
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3 Biogenesis and cellular dynamics of glycerophospholipids in the yeast Saccharomyces cerevisiae
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, glycerophospholipids are important cellular components required for growth and cell...
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The endocytic TPLATE complex internalizes ubiquitinated plasma membrane cargo
Endocytosis controls the perception of stimuli by modulating protein abundance at the plasma membrane. In plants, clathrin-mediated endocytosis is...
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Physiological and genetic regulation of anhydrobiosis in yeast cells
Anhydrobiosis is a state of living organisms during which their metabolism is reversibly delayed or suspended due to a high degree of dehydration....
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Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
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Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Lifespan regulation by targeting heme signaling in yeast
Heme is an essential prosthetic group that serves as a co-factor and a signaling molecule. Heme levels decline with age, and its deficiency is...
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Unravelling bacterial virulence factors in yeast: From identification to the elucidation of their mechanisms of action
Pathogenic bacteria employ virulence factors (VF) to establish infection and cause disease in their host. Yeasts, Saccharomyces cerevisiae and Saccharo...
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Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins
Supported by an endogenous killer plasmid DNA system that codes for an anti-proliferative zymocin toxin, the dairy yeast Kluyveromyces lactis has...