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Discovery of Bioactive Metabolites from the Genus Arthrinium
The ascomycete genus Arthrinium (class, Sordariomycetes; family, Apiosporaceae) comprises approximately 88 species distributed worldwide. It has been...
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The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance
Cancers such as breast, colon, and lung cancers are among the leading causes of death with alarming increases in the number of new diagnoses and...
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Optimization of salicylic acid and chitosan treatment for bitter secoiridoid and xanthone glycosides production in shoot cultures of Swertia paniculata using response surface methodology and artificial neural network
BackgroundIn this study, response surface methodology (RSM) and artificial neural network (ANN) was used to construct the predicted models of linear,...
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Phenolic Composition of Honeybush and Changes During Herbal Tea and Extract Production
Several Cyclopia species, including C. intermedia, C. subternata, and C. genistoides, are used to make honeybush tea. All species belonging to this...
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Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362
Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives,...
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Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4
To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an...
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Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide. The dietary xanthone α-mangostin (α-MGT) exhibits potent anti-tumor...
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An insight on medicinal attributes of 1,2,3‐ and 1,2,4‐triazole derivatives as alpha-amylase and alpha-glucosidase inhibitors
Diabetes Mellitus (DM) is the globe’s common leading disease which is caused by high consumption of glucose. DM compiles groups of metabolic...
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Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2
For the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several...
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Photoperiod modulates the production of biologically active compounds in Hypericum perforatum L. hairy roots: an in vitro and in silico approach
Hypericum perforatum L. hairy root clones cultured under dark (HR1) and photoperiod (HR2) conditions were comparatively assessed for the contents of...
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Probing Alterations in MDM2 Catalytic Core Structure Effect of Garcinia Mangostana Derivatives: Insight from Molecular Dynamics Simulations
The MDM2–p53 protein–protein interaction is a promising model for researchers to design, study, and discover new anticancer drugs. The design of...
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Biodiversity of Fruit Crops and Utilization in Food and Nutritional Security
The world’s fruit biodiversity is enormous in terms of genetics, species, and ecosystem. America grows about 1000 species of fruits, 500 are found in...
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Conservation of RET Medicinal and Aromatic Plants, Their Traditional Medicines and Current Practices in Indian Himalayan Region
According to WHO, the traditional medicine is the sum total of all the knowledge and practices, however explicable or not, used in diagnosis,...
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Alpha-Mangostin and its nano-conjugates induced programmed cell death in Acanthamoeba castellanii belonging to the T4 genotype
Acanthamoeba are free living amoebae that are the causative agent of keratitis and granulomatous amoebic encephalitis. Alpha-Mangostin (AMS) is a...
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Alpha-mangostin Protects PC12 Cells Against Neurotoxicity Induced by Cadmium and Arsenic
Arsenic and cadmium are nonessential elements that are of importance in public health due to their high toxicity. Contact with these toxic elements,...
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A comprehensive molecular docking-based study to identify potential drug-candidates against the novel and emerging severe fever with thrombocytopenia syndrome virus (SFTSV) by targeting the nucleoprotein
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging haemorrhagic fever that is caused by an RNA virus called Severe fever with...
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Mesua ferrea L.: Ethnobotany, Phytochemistry and Pharmacology
The plant kingdom has plenty of plants with herbal activities. Amongst them Mesua ferrea, also known as “Nagakesar”, is a species with several...
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Nature Interpretation Sites: A New Hope of Ex-situ Garden for Conservation and Cultivation of Economically Important RET MAPs in Higher Himalayan Regions
The Himalayan mountain ecosystem offers a wide range of goods and services to humanity, benefiting both mountain dwellers and non-mountain dwellers....
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Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties
Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high...
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Chitosan oligosaccharides affect xanthone and VOC biosynthesis in Hypericum perforatum root cultures and enhance the antifungal activity of root extracts
Key messageWater-soluble chitosan oligosaccharides (COS) affect xanthone and volatile organic compound content, as well as antifungal activity...
