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Wnt/β-catenin signaling pathway in liver biology and tumorigenesis
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway that controls fundamental physiological and pathological processes by...
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PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation
BackgroundPaired box 1 (PAX1) is a transcription factor and essential for the development of pharyngeal pouches-derived tissues, including thymus....
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BML-281 promotes neuronal differentiation by modulating Wnt/Ca2+ and Wnt/PCP signaling pathway
Histone deacetylase (HDAC) inhibitors promote differentiation through post-translational modifications of histones. BML-281, an HDAC6 inhibitor, has...
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Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set...
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Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
BackgroundPrimary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate...
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WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway
Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is compensated by generating new cells with the capacity for...
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miR-199a-5p modulates choroidal neovascularization by regulating Wnt7b/Wnt/β-catenin signaling pathway
Choroidal neovascularization (CNV) can be seen in many fundus diseases, and lead to fundus exudation, bleeding, or vision loss. miRNAs are vital...
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Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its...
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Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis
Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of...
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Annexin A9 promotes cell proliferation by regulating the Wnt signaling pathway in colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Expression of Annexin A9 (ANXA9), a member of the annexin...
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IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/β-catenin signaling pathway
Extranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to...
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Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer
Aberrant canonical Wnt signaling is a hallmark of colon cancer. The TP53 tumor suppressor gene is altered in many solid tumors, including colorectal...
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Wnt signaling in cardiac development and heart diseases
The Wnt signaling pathway is a fundamental cellular communication system with extensive implications in various organs including the heart. In...
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Nuclear receptor NURR1 functions to promote stemness and epithelial-mesenchymal transition in prostate cancer via its targeting of Wnt/β-catenin signaling pathway
Dysregulated activation of Wnt/β-catenin signaling pathway is a frequent or common event during advanced progression of multiple cancers. With this...
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Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway
Ankle osteoarthritis is a relatively understudied condition and the molecular mechanisms involved in its development are not well understood. This...
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Interference KRT17 reverses doxorubicin resistance in triple-negative breast cancer cells by Wnt/β-catenin signaling pathway
BackgroundTriple-negative breast cancer (TNBC) is a subtype of breast cancer with the highest degree of malignancy and is easily resistant to drugs...
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Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway
BackgroundXerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment...
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POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/β-catenin signaling pathway
Lymphoma is the most common malignant tumor arising from immune system. Recently, DNA polymerase epsilon subunit 2 (POLE2) was identified to be a...
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Connection between MiR-490 and CCND1 and GSK3β genes play an effective role in Wnt signaling pathway in colorectal cancer
The Wnt signaling pathway is identified as one of the main disrupted pathways in Colorectal cancer (CRC). Results from studies focusing on this route...
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MicroRNAs regulating Wnt signaling pathway in colorectal cancer: biological implications and clinical potentials
Colorectal cancer (CRC) is one of the most frequent cancers leading to death worldwide. Different signaling pathways such as the canonical Wnt...
